Eosinophilic Esophagitis, also called EE or EoE, is a chronic immune system disease. In patients with EoE, there is a buildup of a type of white blood cell called eosinophils in the tissue of the esophagus, the pathway that sends food from the mouth to the stomach. These cells produce a protein that causes inflammation or swelling of the esophagus. This swelling can lead to scarring and narrowing of the esophagus, making it difficult to swallow.
The most common symptom of eosinophilic esophagitis is difficulty swallowing solid food and impaction, where food is lodged in the esophagus, unable to pass into the stomach. In adults with EoE, chest pain, persistent heartburn, and upper abdominal pain may be present. Children with EoE may be difficult to feed and have poor growth and malnutrition.
Researchers believe both genetic and environmental factors result in the development of Eosinophilic esophagitis. A history of allergic conditions and reactions is seen in the majority of patients with EoE. These reactions, either to food or airborne allergens, lead to inflammation and injury of esophageal tissue. Many patients notice the symptoms of their EoE worsen during allergy season.
After a diagnosis of eosinophilic esophagitis has been made, it is important to schedule an appointment with an allergist to determine any allergy related issues that may be contributing your symptoms. Dietary changes may be helpful in treatment of this disease.
Medications to treat inflammation and acid production are often recommended during treatment. It is important to speak with your gastroenterologist about methods and treatments that may work for you.
Current Trials for Eosinophilic Esophagitis
We currently have no trials enrolling for patients with Eosinophilic Esophagitis. Talk with your doctor about upcoming trials or other treatment options available.