After surviving a critical illness, many patients and families experience lingering effects. New or worsening impairments in physical function, cognition, and psychological health may persist for months or years. These impairments, collectively known as the post intensive care syndrome (PICS), are only beginning to be understood. At Vanderbilt, we seek to understand how PICS affects recovery from critical illness, and how these effects impact patients, families, health care, and larger systems.

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Currently enrolling trials:

Addressing Post Intensive Care Syndrome (APICS). This is a multicenter, prospective, observational study of survivors of acute lung injury that assesses the relationship between early unmet needs following critical illness and subsequent clinical outcomes.

Telehealth Enhanced Patient Oriented Recovery Trajectory after ICU (TelePORT ICU). This is a clinical trial comparing the effectiveness of in person vs telehealth post-ICU clinic intervention. This study is of critical importance in determining alternative clinical strategies that meet the needs of high risk patients recovering from critical illness.

Impact of Solitude On Patients, Loved Ones And Healthcare Teams' Experience in the ICU (ISOLATE-ICU). This is a mixed methods study of patients, caregivers, and healthcare providers that seeks to exam the effects of isolation on the experience of giving and receiving critical care in the era of COVID-19.  

Pulmonary Fibrosis After COVID-19 (PFAC). This study builds on prior research by unifying our interstitial lung disease (ILD) research group, the Vanderbilt COVID-19 Consortium Cohort (VC3), and the ICU Recovery Center at Vanderbilt to examine pulmonary fibrosis as a sequela of severe SARS-CoV-2 infection. 

Cognitive Outcomes in the Pragmatic Investigation of Optimal Oxygen Targets (CO-PILOT) Trial.  This study evaluates the effects of higher, intermediate, and lower oxygen saturation targets during mechanical ventilation on long-term patient-important outcomes.