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Virtual Grand Rounds
Patricia Brubaker, Ph.D., F.R.S.C.
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Patricia Brubaker is Professor in the Departments of Physiology and Medicine at the University of Toronto. Dr. Brubaker graduated with a B.Sc. and Ph.D. in Biochemistry from McGill University in Montreal, and undertook post-doctoral training at the University of Toronto in the Department of Physiology. She joined the Department of Physiology as a faculty member in 1985.

With the support of operating grants from, most notably, the Canadian Diabetes Association and the Canadian Institutes of Health Research, Dr. Brubaker has authored more than 200 publications in international journals, including several book chapters and invited editorials. She is the recipient of the Young Scientist Award from the Canadian Diabetes Association (1998), the Sarrazin Award Lectureship for a Distinguished Speaker from the Canadian Physiological Society (2018), and the Lifetime Achievement Award from Diabetes Canada (2020). She has held a Tier 1 Canada Research Chair since 2001, and was inducted as a Fellow of the Royal Society of Canada in 2016. She has trained nearly 60 graduate students and post-doctoral fellows, as well as over 150 undergraduate students, and has received over one dozen awards for her teaching at the University of Toronto.

Dr. Brubaker’s research interests have focused on the synthesis, secretion and biological activities of the intestinal proglucagon-derived peptides, most notably glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2). Her studies have contributed to our understanding of the clinically-important actions of long-acting analogs of GLP-1 for use in patients with type2 diabetes and obesity, and of GLP-2 receptor agonists for patients with short bowel syndrome. Her recent interests have focused on the circadian patterns of secretion of these peptides, with translational implications for the development of metabolic disease in individuals such as shift-workers.

Over the past decade, Dr. Brubaker has had a particular interest in the history of the discovery of insulin, having contributed to the creation of a permanent Discovery of Insulin display at the University of Toronto, as well as to multiple national and international events and the development of a Canada Post stamp, all celebrating the 100th anniversary of the discovery of insulin.
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Sponsored by Vanderbilt School of Medicine; Department of Medicine. Vanderbilt School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Vanderbilt School of Medicine designates this live activity for a maximum of 1.0 <i>AMA PRA Category 1 Credit(s)<sup>TM</sup></i>. Physicians should only claim credit commensurate with the extent of their participation in the activity. It is the policy of Vanderbilt School of Medicine that participants in CME activities be made aware of any affiliation or financial interest that may affect the planner’s involvement and speaker’s presentation(s). Each planner and speaker has completed and signed a conflict of interest statement; these relationships will be disclosed to the audience. This educational activity received no commercial support.
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