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Endotoxin shock protector

November 08, 2019

The bacterial toxin lipopolysaccharide (LPS) is one of the most potent virulence factors of Gram-negative bacteria that cause sepsis. Exposure to even tiny amounts can trigger a systemic — and potentially lethal — inflammatory response known as endotoxin shock.

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A new regulator of B cell development

October 10, 2019

Interleukin-33 (IL-33) drives inflammatory responses in allergic and nonallergic disease. Epithelial cells in the lungs, gastrointestinal tract and elsewhere release IL-33, which activates the ST2 receptor on immune cell targets.

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Study shines light on architecture of kidney disease

September 27, 2019

A study of 280,000 U.S. veterans including 56,000 African Americans has identified in greater detail than ever before the “genetic architecture” of kidney function and chronic kidney disease (CKD), according to researchers at Vanderbilt University Medical Center and their colleagues.

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