Associate Professor of Medicine
Cardiovascular Medicine

Associate Professor of Medicine, Cardiovascular Medicine

Medical Director, Cardiovascular Intensive Care Unit

Professional Bio

Dr. DeFilippis is a translational researcher leveraging his expertise in cohort development, clinical cardiology, cardiovascular epidemiology, and acute myocardial infarction (MI) to better understand, diagnose, and predict the full spectrum of myocardial injury events, specifically subtypes of MI. Dr. DeFilippis is a board-certified cardiologist and Medical Director of the Cardiovascular Intensive Care Unit at Vanderbilt. Dr. Defilippis has significant experience evaluating cardiovascular risk prediction in the Multi-Ethnic Study of Atherosclerosis (MESA) and serves on the MESA Project and Publication Committee. Dr. DeFilippis also has significant experience in acute MI diagnosis, treatment, and research. He serves on the steering committee for the NIH-sponsored multicenter Myocardial Ischemia and Transfusion (MINT) trial. Dr. DeFilippis has adjudicated over 800 cases for presence of acute MI as part of a diagnostic of a point of care troponin assay seeking FDA approval. Dr. DeFilippis’ work has been published in multiple peer-reviewed journals, including Annals of Internal Medicine, The Lancet, and Journal of the American College of Cardiology. He recently published an invited Viewpoint in Circulation Research, “Myocardial Infarction as a Clinical Endpoint in Research—What Are We Really Talking About?” and a White Paper in Circulation, “Assessment and Treatment of Patients with Type 2 Myocardial Infarction and Acute Non-Ischemic Myocardial Injury.” Dr. DeFilippis is the principal investigator on NIH, foundation, and industry grants and works with an international team of collaborators on innovative projects to advance our ability to more effectively prevent, diagnose, and treat cardiovascular disease.


MD - Georgetown University School of Medicine - 2001
Residency - Internal Medicine - Emory University School of Medicine - 2004
MS - Emory University School of Medicine - 2006
Fellowship - Cardiovascular Medicine - Johns Hopkins University School of Medicine, - 2011
Fellowship - Proteomics - Johns Hopkins University School of Medicine, - 2011