Carlos Henrique Serezani, PhD
1161 21st Avenue South, Medical Center North, Room / Suite A2200, Nashville, TN 37232, Phone 615-322-2035
Associate Professor of Medicine, Department of Medicine, Division of Infectious Diseases
The Serezani laboratory aims to develop therapeutic strategies to control systemic (sepsis) and localized infections (skin and lung) in healthy individuals, individuals with immune deficiencies, and those suffering from chronic inflammatory diseases, such as diabetes. We have concentrated much of our efforts in understanding the role of the lipid mediators leukotriene B4 and prostaglandin E2 and their actions on microRNAs, epigenetic changes and phosphatases to modulate immune cells involved in the control of microbial infection in these different contexts. Our lab employs state of the art techniques to understand in vitro and in vivo cellular and microbial dynamics, such as intravital microscopy and IVIS imaging, along with different fluorescent and cell-specific deficient mice to track cell and organ-specific events.
Diabetes, sepsis. innate immunity, macrophage, host defense, microRNAs, neutrophils, lung injury, skin infection, SOCS-1, abscess, immunotherapy