Office Address:
1285 MRB4 (0575), Nashville, TN 37232-0575

Interim Director, Division of Cardiovascular Medicine

Director, Oates Institute for Experimental Therapeutics

Professor of Medicine and Pharmacology, and Biomedical Informatics

Senior Vice President for Personalized Medicine

Education

MD - McGill

Postgraduate Training

Internship

Royal Victoria Hospital, 1975

Residency

Royal Victoria Hospital, 1978

Fellowship

Vanderbilt University Medical Center, 1981

Post_Graduate_Training - McGill University Hospital

Board and Certifications
  • Internal Medicine - American Board of Internal Medicine, 1978
  • Cardiovascular Disease - American Board of Internal Medicine, 1981
  • Clinical Pharmacology - American Board of Clinical Pharmacology, 1993

Clinical Interest

Areas of Expertise

  • Arrhythmia and Electrophysiology
  • Arrhythmias
  • Cardiovascular Medicine
  • Hypertrophic Cardiomyopathy & Inherited Disease
Research Keywords
Drug metabolism, Genetics, Heart, Ion transport, Knockout, Mouse, Pharmacokinetics, Pharmacology, Polymorphism
Research Description

Abnormalities of cardiac rhythm are a common and serious public health problem. However, the therapies used to treat arrhythmias are often ineffective, and can sometimes even exacerbate arrhythmias. Research in this laboratory is directed at elucidating mechanisms underlying abnormalities of cardiac rhythm and mechanisms underlying variable responses to antiarrhythmic drug treatments. Since antiarrhythmic drugs affect the function of cardiac ion channels, it is one working hypothesis in the laboratory that variable responses to drug therapy may reflect variable function or expression of genes encoding ion channels or proteins involved in drug disposition. Thus, a major focus of work in the laboratory is elucidation of factor(s) that determine ion channel gene expression in cardiac tissue. Approaches include identification of new genes, identification of DNA polymorphisms and characterization of their functional effects on disease and drug responses, and modulation of expression in cultured heart cells (e.g. by antisense) and gene knockout in mice.