Jeeyeon Cha, MD, PhD
Instructor of Medicine, Division of Diabetes, Endocrinology, & Metabolism
Jeeyeon was born in S. Korea and spent her early years in Chicago, IL and Morgantown, WV. When her parents and younger brother John moved back to Korea, she decided to stay with her aunt and uncle in Fort Thomas, KY for high school. She attended the University of Cincinnati (UC) with a major in Biomedical Engineering through the Connections-E (BS/MD) Dual Admissions Program and developed an interest for basic research as a lab aide in the Wylie-Heasman lab at Cincinnati Children’s. Following graduation, she joined the UC MSTP and earned her PhD in Developmental Biology and Reproductive Sciences under the mentorship of S. K. Dey at Cincinnati Children’s. Jeeyeon is very excited to continue her medical and research training at Vanderbilt as a Harrison Society Scholar and live in Nashville. In her spare time, Jeeyeon enjoys running, traveling, and spending time with friends and family.
1. Cha J, Birsoy B, Kofron M, Mahoney E, Lang S, Wylie C, Heasman J. The Role of FoxC1 in Early Xenopus Development. Developmental Dynamics 236(10): 2731-41, 2007.
2. Hirota Y, Cha J, Dey SK. Revisiting Reproduction: Prematurity and the Puzzle of Progesterone Resistance. Nature Medicine 16(5): 529-31, 2010.
3. Cha J & Browne A. Gastrointestinal Drugs. Andrew W. Browne & Margaret A. Stefater (Eds.), In Pharmacology You See: A high yield pharmacology review for health professionals (pp.115-123). Toronto, Ontario, Canada: Toronto Notes, 2011. Book Chapter.
4. Hirota Y, Cha J, Yoshie M, Daikoku T, Dey SK. Heightened uterine mTORC1 signaling provokes preterm birth in mice. Proceedings of the National Academy of Sciences, USA 108(44): 18073-18078, 2011.
5. Daikoku T*, Cha J*, Sun X, Tranguch S, Huirong X, Fujita T, Hirota Y, Lydon J, DeMayo F, Maxson R, Dey SK. Conditional deletion of MSX homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity. Developmental Cell 21(6):1014-25, 2011. *Equal contribution
6. Cha J, Hirota Y, Dey SK. Sensing Senescence in Preterm Birth. Cell Cycle 11(2): 205-206, 2012.
7. Cha J, Sun X, Dey SK. Mechanisms of implantation: strategies for successful pregnancy. Nature Medicine 18(12): 1754-67, 2012. Review article.
8. Daikoku T, Yoshie M, Xie H, Sun X, Cha J, Ellenson LH, Dey SK. Conditional deletion of Tsc1 impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice. Molecular Human Reproduction, 19(7): 463-72, 2013.
9. Cha J, Sun X, Bartos A, Fenelon J, Lefevre P, Daikoku D, Shaw G, Maxson R, Murphy BD, Renfree MB, Dey SK. A new role for muscle segment homeobox genes in mammalian embryonic diapause. Open Biology (Royal Society) 3(4):130035, 2013.
10. Cha J, Bartos A, Egashira M, Haraguchi H, Saito-Fujita T, Leishman E, Bradshaw H, Dey SK, Hirota Y. Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions. Journal of Clinical Investigation, 123(9):4063-75, 2013.
11. Laskin J, Lanekoff I, Burnum-Johnson K, Thomas M, Short J, Carson J, Cha J, Dey SK, Yang P, Prieto-Conaway M. High-Speed MS/MS in Situ Imaging by Nanospray Desorption Electrospray Ionization Mass Spectrometry. Analytical Chemistry, 85(20): 9596-603, 2013.
12. Cha J, Vilella F, Dey SK, Simon C. Molecular Interplay in Successful Implantation in Ten Critical Topics in Reproductive Medicine, S. Sanders, Ed. Science/AAAS, Washington, DC, pp. 44-48, 2013.
13. Cha J, Lim H, Dey SK. Embryo Implantation. Knobil and Neill’s Physiology of Reproduction. Eds. Tony M. Plant and Anthony J. Zeleznik. Elsevier, New York. pp. 1697-1739, 2014. 4th edition. Book Chapter.
14. Cha J & Dey SK. Cadence to procreation: orchestration of embryo-uterine interactions. Seminars in Cell & Developmental Biology, 34C: 56-64, 2014.
15. Haraguchi H, Saito-Fujita T, Hirota Y, Egashira M, Matsumoto L, Matsuo M, Koga K, Yamauchi N, Fukayama F, Bartos A, Cha J, Dey SK, Fujii T, Osuga Y. Progesterone signaling mediated by microRNA-200a is critical for endometrial proliferation-differentiation switch and embryo implantation. Molecular Endocrinology, 28(7): 1108-1117, 2014.
16. Cha J, Bartos A, Park C, Sun X, Cha SW, Ho H, Yamaguchi T, Dey SK. Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling. Cell Reports, 24;8(2):382-92, 2014.
17. Lanekoff I, Burnum-Johnson K, Thomas M, Cha J, Dey SK, Yang P, Prieto-Conaway M, Laskin J. Three-Dimensional In Situ Tissue Imaging by Nanospray Desorption Electrospray Ionization Mass Spectrometry to localize biological molecules. Analytical and Bioanalytical Chemistry, 407(8):2063-71, 2015.
18. Cha J*, Burnum-Johnson KE*, Bartos A, Li Y, Baker ES, Tilton SC, Webb-Robertson BJ, Piehowski PD, Monroe ME, Jegga AG, Murata S, Hirota Y, Dey SK. Muscle segment homeobox genes direct embryonic diapause by limiting inflammation in the uterus. Journal Biological Chemistry, 290(24):15337-49, 2015. *Equal contribution
19. Cha J, Dey SK. Reflections on Rodent Implantation: A Tribute to Roger Short. Advances in Anatomy, Embryology, and Cell Biology. Rodney D. Geisert, Fuller W. Bazer (Eds). Bern: Springer. 216:69-85, 2015. Book Chapter.
20. Kyle JE, Zhang X, Weitz KK, Monroe ME, Ibrahim YM, Moore RJ, Cha J, Sun X, Lovelace ES, Wagoner J, Polyak SJ, Metz TO, Dey SK, Smith RD, Burnum-Johnson KE, Baker ES. Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry. Analyst (Royal Society of Chemistry). 141(5): 1649-59, 2016.
21. Sones JL*, Cha J*, Woods AK, Bartos A, Heyward CY, Lob HE, Isroff CE, Butler SD, Shapiro SE, Dey SK, Davisson RL. Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model. JCI Insight. 1(3):e75351, 2016. *Equal contribution
22. Deng W*, Cha J*, Haraguchi H, Bartos A, Viollet B, Bradshaw H, Hirota Y, Dey SK. p53 coordinates decidual Sestrin2-AMPK-mTORC1 signaling to govern parturition timing. Journal of Clinical Investigation. 126(8):2941-54, 2016. In Press. *Equal contribution
23. Yuan J*, Cha J*, Deng W, Bartos A, Sun X, Ho HYH, Borg JP, Yamaguchi T, Yang Y, Dey SK. PCP signaling directs epithelial evaginations and engages Noggin-Bmp2 interaction for blastocyst attachment. Proceedings of the National Academy of Sciences, USA. 113(50): E8079-E8088, 2016. *Equal contribution
24. Cha J & Dey SK. Hunting for Fox(A2): Dual roles in female fertility. Proceedings of the National Academy of Sciences, USA, pii: 201620648, 2016.