Research Fellow, Division of Diabetes, Endocrinology and Metabolism

Cincinnati Children's

Hometown
Fort Thomas, KY / Taejon, S. Korea
Previous Role/Title
Research Fellow, Division of Diabetes, Endocrinology and Metabolism

Education

University of Cincinnati College of Medicine
B.S. - Tulane Univ
BS - Tulane University
Professional Highlights

Education

2015-2017                   Residency in Internal Medicine

                                    Vanderbilt University Medical Center

                                    Nashville, Tennessee

 

2007-2015                   M.D., University of Cincinnati College of Medicine

                                    Physician Scientist Training Program

                                    University of Cincinnati, Cincinnati, Ohio

 

2009-2013                   Ph.D., Molecular and Developmental Biology

                                    Cincinnati Children’s Research Foundation

                                    Advisor: Sudhansu K. Dey

 

2002-2007                   B.Sc. in Biomedical Engineering

                                    University of Cincinnati, Cincinnati, Ohio 

Publications

1. Cha J, Birsoy B, Kofron M, Mahoney E, Lang S, Wylie C, Heasman J. The Role of FoxC1 in Early Xenopus Development. Developmental Dynamics 236(10): 2731-41, 2007.

2. Hirota Y, Cha J, Dey SK. Revisiting Reproduction: Prematurity and the Puzzle of Progesterone Resistance. Nature Medicine 16(5): 529-31, 2010.

3. Cha J & Browne A. Gastrointestinal Drugs. Andrew W. Browne & Margaret A. Stefater (Eds.), In Pharmacology You See: A high yield pharmacology review for health professionals (pp.115-123). Toronto, Ontario, Canada: Toronto Notes, 2011. Book Chapter.

4. Hirota Y, Cha J, Yoshie M, Daikoku T, Dey SK. Heightened uterine mTORC1 signaling provokes preterm birth in mice. Proceedings of the National Academy of Sciences, USA 108(44): 18073-18078, 2011.

5. Daikoku T*, Cha J*, Sun X, Tranguch S, Huirong X, Fujita T, Hirota Y, Lydon J, DeMayo F, Maxson R, Dey SK. Conditional deletion of MSX homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity. Developmental Cell 21(6):1014-25, 2011. *Equal contribution

6. Cha J, Hirota Y, Dey SK. Sensing Senescence in Preterm Birth. Cell Cycle 11(2): 205-206, 2012.

7. Cha J, Sun X, Dey SK. Mechanisms of implantation: strategies for successful pregnancy. Nature Medicine 18(12): 1754-67, 2012. Review article.

8. Daikoku T, Yoshie M, Xie H, Sun X, Cha J, Ellenson LH, Dey SK. Conditional deletion of Tsc1 impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice. Molecular Human Reproduction, 19(7): 463-72,  2013.

9. Cha J, Sun X, Bartos A, Fenelon J, Lefevre P, Daikoku D, Shaw G, Maxson R, Murphy BD, Renfree MB, Dey SK. A new role for muscle segment homeobox genes in mammalian embryonic diapause. Open Biology (Royal Society) 3(4):130035, 2013.

10. Cha J, Bartos A, Egashira M, Haraguchi H, Saito-Fujita T, Leishman E, Bradshaw H, Dey SK, Hirota Y. Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions. Journal of Clinical Investigation, 123(9):4063-75, 2013.                  

11. Laskin J, Lanekoff I, Burnum-Johnson K, Thomas M, Short J, Carson J, Cha J, Dey SK, Yang P, Prieto-Conaway M. High-Speed MS/MS in Situ Imaging by Nanospray Desorption Electrospray Ionization Mass Spectrometry. Analytical Chemistry, 85(20): 9596-603, 2013.

12. Cha J, Vilella F, Dey SK, Simon C. Molecular Interplay in Successful Implantation in Ten Critical Topics in Reproductive Medicine, S. Sanders, Ed. Science/AAAS, Washington, DC, pp. 44-48, 2013.

13. Cha J, Lim H, Dey SK. Embryo Implantation. Knobil and Neill’s Physiology of Reproduction. Eds.  Tony M. Plant and Anthony J. Zeleznik. Elsevier, New York. pp. 1697-1739, 2014. 4th edition. Book Chapter.

14. Cha J & Dey SK. Cadence to procreation: orchestration of embryo-uterine interactions. Seminars in Cell & Developmental Biology, 34C: 56-64, 2014.

15. Haraguchi H, Saito-Fujita T, Hirota Y, Egashira M, Matsumoto L, Matsuo M, Koga K, Yamauchi N, Fukayama F, Bartos A, Cha J, Dey SK, Fujii T, Osuga Y. Progesterone signaling mediated by microRNA-200a is critical for endometrial proliferation-differentiation switch and embryo implantation. Molecular Endocrinology, 28(7): 1108-1117, 2014.

16. Cha J, Bartos A, Park C, Sun X, Cha SW, Ho H, Yamaguchi T, Dey SK. Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling. Cell Reports, 24;8(2):382-92, 2014.

17. Lanekoff I, Burnum-Johnson K, Thomas M, Cha J, Dey SK, Yang P, Prieto-Conaway M, Laskin J. Three-Dimensional In Situ Tissue Imaging by Nanospray Desorption Electrospray Ionization Mass Spectrometry to localize biological molecules. Analytical and Bioanalytical Chemistry, 407(8):2063-71, 2015.

18. Cha J*, Burnum-Johnson KE*, Bartos A, Li Y, Baker ES, Tilton SC, Webb-Robertson BJ, Piehowski PD, Monroe ME, Jegga AG, Murata S, Hirota Y, Dey SK. Muscle segment homeobox genes direct embryonic diapause by limiting inflammation in the uterus. Journal Biological Chemistry, 290(24):15337-49, 2015. *Equal contribution

19. Cha J, Dey SK. Reflections on Rodent Implantation: A Tribute to Roger Short. Advances in Anatomy, Embryology, and Cell Biology. Rodney D. Geisert, Fuller W. Bazer (Eds). Bern: Springer. 216:69-85, 2015. Book Chapter.

20. Kyle JE, Zhang X, Weitz KK, Monroe ME, Ibrahim YM, Moore RJ, Cha J, Sun X, Lovelace ES, Wagoner J, Polyak SJ, Metz TO, Dey SK, Smith RD, Burnum-Johnson KE, Baker ES. Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry. Analyst (Royal Society of Chemistry). 141(5): 1649-59, 2016.

21. Sones JL*, Cha J*, Woods AK, Bartos A, Heyward CY, Lob HE, Isroff CE, Butler SD, Shapiro SE, Dey SK, Davisson RL. Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model. JCI Insight. 1(3):e75351, 2016. *Equal contribution

22. Deng W*, Cha J*, Haraguchi H, Bartos A, Viollet B, Bradshaw H, Hirota Y, Dey SK. p53 coordinates decidual Sestrin2-AMPK-mTORC1 signaling to govern parturition timing. Journal of Clinical Investigation. 126(8):2941-54, 2016. In Press. *Equal contribution

23. Yuan J*, Cha J*, Deng W, Bartos A, Sun X, Ho HYH, Borg JP, Yamaguchi T, Yang Y, Dey SK. PCP signaling directs epithelial evaginations and engages Noggin-Bmp2 interaction for blastocyst attachment. Proceedings of the National Academy of Sciences, USA. 113(50): E8079-E8088, 2016. *Equal contribution

24. Cha J & Dey SK. Hunting for Fox(A2): Dual roles in female fertility. Proceedings of the National Academy of Sciences, USA, pii: 201620648, 2016.