John R. Koethe, M.D.
1211 21st Avenue South, Medical Arts Building, Room / Suite 102A, Nashville, TN, TN 37212
1161 21st Avenue South, Medical Center North, Room / Suite A2200, Nashville, TN , TN 37232-2582
Associate Professor of Medicine
Dr. Koethe is a board certified infectious diseases physician and researcher. His focus is how the interaction of HIV infection and nutritional host factors, such as obesity, affects the risk of metabolic disease among patients on long-term HIV treatment. He received formal training in clinical and translational research design and methods, and biostatistics from the Vanderbilt Masters of Science in Clinical Investigation Program (2010-2012). He is currently supported by a career development grant from NIAID (K23AI100700) to study 1) how total adiposity and adipose tissue distribution affect innate and adaptive immune function in HIV-infected individuals, and 2) how obesity alters the phenotype of HIV-associated cardiometabolic disease in a well-characterized 100 participant clinical cohort of HIV-infected persons and HIV-negative controls. Recent analyses from this cohort have highlighted novel relationships between circulating T cell subsets, metabolic and cardiovascular health parameters, metabolomic profiles, and plasma biomarkers. Additionally, a sub-cohort has undergone adipose tissue biopsies to study the distribution of circulating versus adipose-resident T cell subsets, and characterize T cell receptor clonality (via TCR sequencing) in the two tissue compartments. Dr. Koethe is also the PI of a NIDDK-supported study (R56DK108352) to assess the relationships between circulating T cell profiles and the risk of incident diabetes among the 2300 HIV-infected and HIV-negative participants in the Veterans Aging Cohort Study (VACS).