Office Address:
1161 21st Ave S., T-1218 MCN, Medical Center North, Room / Suite T-1218, Nashville, TN 37232-2650

Associate Professor of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine

Hometown
Turners Falls, MA
Previous Role/Title
Associate Professor of Medicine, Cell and Developmental Biology and Pathology and Microbiology & Immunology, Associate Program Director for Resident Research, Internal Medicine, Faculty, Center for Precision Medicine

Education

MD - Vanderbilt University
BA, Biology, College of the Holy Cross, Worcester, Massachusetts

Clinical Interest

Dr. Bastarache currently sees patients at the Veterans Affairs Medical Center in Nashville, TN in both the ICU and inpatient medical wards. She is also Medical Director of the MICU and has a particular clinical interest in sepsis, ARDS and non-pulmonary organ dysfunction.
Research Keywords
<div><font face='Open Sans' size=3 color='#333333'>Acute Respiratory Distress Syndrome (ARDS), sepsis, alveolar-capillary barrier dysfunction, delirium, non-pulmonary organ dysfunction, coagulation, tissue factor, cell-free hemoglobin, glycocalyx, vitamin C, single cell RNA Seq, tissue mass spectrometry, precision medicine, BioVU, bronchiectasis, cystic fibrosis.</font></div>
Research Description

The goal of my research program is to understand the pathophysiology of acute respiratory distress syndrome (ARDS) and sepsis and to uncover novel approaches to prevention and treatment of these devastating conditions. As a physician-scientist, my aim is to uncover novel mechanisms that contribute to the development of sepsis and ARDS with the ultimate goal of identifying new biologic targets and unique therapeutic approaches that can be translated to clinical practice. My lab has two major focus areas: the role of cell free-hemoglobin in modulating endothelial and lung epithelial permeability in sepsis and ARDS and the role of tissue factor, the initiator of the extrinsic coagulation cascade, in mediating lung epithelial injury and repair. I have experience with mouse models of acute lung injury as well as with modeling the epithelial barrier for in vitro study. I have developed several novel murine and cell culture model systems to study the function of TF in ALI. My research is translational and combines studies in cell culture, human and mouse experimental models, and human samples from patients with sepsis and ARDS.