Leslie S. Gewin, MD
1161 21st Avenue South, Medical Center North, Room / Suite S-3223, Nashville, TN, TN 37232
Associate Professor of Medicine
The Gewin laboratory is interested in the pathophysiology of renal injury and tubulointerstitial fibrosis with a specific interest in tubule epithelial injury. Renal tubule epithelial cells, particularly proximal tubules, are both vulnerable to kidney injury but also play an important role in the progression of chronic kidney disease. Our group is focused on understanding how growth factors, particularly the TGF-beta and Wnt/beta-catenin pathways, modulate the epithelial response to injury. We use mouse models with renal tubule-specific alterations in these growth factor pathways and study how those altered pathways affect the response to injury. The Gewin laboratory is also interested in alterations in metabolism, cell cycle, and mitochondrial function in the injured proximal tubule and how TGF-beta and Wnt/beta-catenin affect these responses to stress. In addition to in vivo models, we use cell culture and molecular biology techniques to better define mechanisms of injury. By improving our understanding of epithelial repair mechanisms, we hope to identify better targets for the treatment of chronic kidney disease.