Matthew H. Wilson, PhD, MD
Associate Professor of Medicine
Our laboratory uses non-viral gene transfer to ask biological questions relevant to kidney disease and to engineer new therapeutic approaches for kidney disease. We use the piggyBac transposon system (and other transposon systems) for most of our studies. Currently, our lab is focused on two broad projects. One involves gene-modifying long-lived antigen-specific T cells for cell therapy of anemia. In this strategy, T cells are used as a celluar vehicle to inducibly express erythropoietin (EPO) resulting in drug regulated EPO production. The second broad project involves non-viral gene transfer to kidney directly. We are attempting to phenotypically correct cystinuria in a mouse model of this human disease. The goal is to use gene transfer to express a lacking cystine transporter in proximal tubular cells in vivo. We are also interested in engineering transposons to be more site-directed and efficient in gene transfer applications.