Assistant Professor of Medicine
Allergy, Pulmonary, and Critical Care Medicine

Assistant Professor of Medicine

Professional Bio

Matthew W. Semler MD, MSc, is an Assistant Professor of Medicine and Biomedical Informatics in the Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, at Vanderbilt University Medical Center. He is a critical care physician and Associate Director of the Medical Intensive Care Unit at VUMC.  

Dr. Semler received his Bachelors of Science and Medical Doctorate from the University of Virginia before completing residency and chief residency in internal medicine and fellowship in pulmonary and critical care medicine at Vanderbilt. His federally-funded research identifies non-patient-centered variation in current clinical practice, embeds pragmatic randomized trials into clinical care to understand which treatments produce the best outcomes for which patients, and implements the results into practice. Randomized trials he has helped lead, including six published in the New England Journal of Medicine or JAMA, have challenged longstanding dogma around common practices in fluid management, airway management, and respiratory support.

Dr. Semler serves as Chair of the Steering Committee for the Pragmatic Critical Care Research Group, co-director of the Inpatient Division of the Learning Healthcare System at Vanderbilt University, and a member of the protocol committee for trials within the NHLBI PETAL Network.  


MD - University of Virginia School of Medicine - 2008
Internship - Internal Medicine - Vanderbilt University Medical Center - 2009
Residency - Internal Medicine - Vanderbilt University Medical Center - 2011
Residency - Chief Resident-Internal Medicine - Vanderbilt University Medical Center - 2012
MSCI - Vanderbilt University School of Medicine - 2016
Fellowship - Postdoc Allergy Pulmonary - Vanderbilt University Medical Center - 2016