Rachelle W. Johnson, PhD
<div><font color=black>Bone metastasis, breast cancer, hypoxia, leukemia inhibitory factor, parathyroid hormone-related protein</font></div>
Assistant Professor of Medicine, Division of Clinical Pharmacology
2215b Garland Ave1255B Medical Research Building IV, Nashville, TN 37232
Dr. Johnson’s research interest is in breast cancer cell dormancy in bone and the process by which quiescent tumor cells transition to proliferative, aggressive cells capable of inducing osteolytic bone destruction. She is also interested in the molecular mechanisms that promote tumor cell metastasis and dissemination to the bone marrow, particularly the role of the hypoxia inducible factor (HIF) and leukemia inhibitory factor (LIF) signaling pathways in this process. Her current efforts are focused on establishing the mechanism by which extreme hypoxia induces tumor colonization of the bone marrow and identifying a dormancy signature for estrogen receptor positive breast cancer cells as they exit dormancy and colonize the bone, with the ultimate goal of identifying potential therapeutic targets for the prevention of tumor recurrence in the bone marrow. To achieve these aims Dr. Johnson utilizes in vitro techniques encompassing molecular and cell biology, RNA sequencing, and datamining of publicly available cancer patient databases (e.g. TCGA, ENCODE), as well as xenograft and transgenic mouse models. Dr. Johnson has received numerous Young Investigator awards and fellowships from the leading national and international organizations in cancer and bone, including the John Haddad Award and Kaye Ibbertson Award and an NIH Pathway to Independence Award from the National Cancer Institute. She was previously elected to the International Bone and Mineral Society (IBMS) Young Investigator Committee and currently serves on the Board for the Cancer and Bone Society (CABS).