Office Address:
1161 21st Avenue South, Medical Center North, Room / Suite S-3223, Nashville, TN, TN 37232-2372

Professor of Medicine

Thomas F. Frist Sr. Chair in Medicine, Vice Chair for Research, Department of Medicine

General Nephrology


M.Med. - Medicine, University of Cape Town, South Africa
Ph.D., Cell Biology - University of Toronto, Toronto, Canada
M.B.B.Ch., Medicine - University of Witwatersrand, Johannesburg, South Africa

Clinical Interest

Research Keywords
Integrin biology, Kidney, Signal transduction, Branching morphogenesis,Kidney,Mouse
Research Description

The laboratory works on the basic role of integrins in epithelial cell biology. We utilize the kidney as a model system and perform biochemical techniques, cell biology and transgenic mice to understand the basic mechanisms whereby integrin-ECM interactions modify cell function. In addition, in collaboration with Dr. Charles Sanders, we perform structural functions on integrins utilizing NMR.