Sergey Dikalov, PhD
Research Associate Professor of Medicine
Our lab studies the diverse pathophysiological role of reactive oxygen species (ROS) such as superoxide radical (O2•), hydrogen peroxide (H2O2), nitric oxide (NO·) and peroxynitrite (ONOO−). We were one of the first groups reported on development of mitochondrial oxidative stress and mitochondrial impairment under conditions of endothelial dysfunction and hypertension. Our lab has uncovered specific molecular mechanisms of mitochondrial ROS upregulation and their contribution in the development of hypertension by overexpression of mitochondrial superoxide dismutase (SOD2) and mitochondria targeted SOD mimetic antioxidants. Our team continues to develop a deeper understanding of the complex redox cell signaling pathways and oxidative stress in the pathogenesis of hypertension and other pathological conditions.