Office Address:
T-1218 MCN, MCN, Room / Suite T-1218, Nashville, TN 37232

Research Instructor in Medicine

Hometown
Japan
Previous Institution
Vanderbilt University Medical Center
Previous Role/Title
Research Instructor in Medicine
Specialty
Allergy and Immunology

Education

PhD - Kochi Medical School
M.Sc., agricultural science, Tokyo University of Agriculture and Technology, Tokyo, Japan
B.S. - Tokyo University of Agricultural Science E

Relevant Links

Clinical Interest

Research Keywords
Obese asthma, mechanisms of allergy, innate lymphoid cells, glucagon-like peptide-1 (GLP-1).
Research Description
Obesity is an important risk factor for asthma in the United States. Previous studies strongly suggest that obese persons with asthma have decreased responsiveness to conventional asthma therapy compared with non-obese persons with asthma, imploring new therapeutic approaches for asthma in the setting of obesity. Glucagon-like peptide-1 receptor (GLP-1R) agonist that is currently being used for the treatment of type-2 diabetes has inhibitory effects of both the early innate and adaptive allergic immune responses. We focused on mechanisms of asthma exacerbation in obesity and hypothesize that GLP-1R signaling is a negative regulator of both innate and adaptive immune responses in aeroallergen-induced asthma model with high-fat diet-induced obesity or polygenic obese mice. Our findings may provide a new therapeutic strategy for uncontrolled asthma with obesity.