Tom Aune, PhD 


Methotrexate and its mechanisms of action in inflammatory arthritis.
Cronstein BN, Aune TM.
Nat Rev Rheumatol. 2020 Mar;16(3):145-154. doi: 10.1038/s41584-020-0373-9. Epub 2020 Feb 17.
PMID: 32066940

Immunoprecipitation of DNA:RNA Hybrids Using the S9.6 Antibody.
Gibbons HR, Aune TM.
Methods Mol Biol. 2020;2161:195-207. doi: 10.1007/978-1-0716-0680-3_14.
PMID: 32681514

A simplified method to produce mRNAs and functional proteins from synthetic double-stranded DNA templates.
Tossberg JT, Esmond TM, Aune TM.
Biotechniques. 2020 Oct;69(4):281-288. doi: 10.2144/btn-2020-0037. Epub 2020 Aug 20.
PMID: 32815735

Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production.
Gibbons HR, Mi DJ, Farley VM, Esmond T, Kaood MB, Aune TM.
Sci Rep. 2019 Jul 16;9(1):10280. doi: 10.1038/s41598-019-46516-x.
PMID: 31311960 

Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds)RNAs Is Markedly Decreased in Multiple Sclerosis and Unedited Alu dsRNAs Are Potent Activators of Proinflammatory Transcriptional Responses.
Tossberg JT, Heinrich RM, Farley VM, Crooke PS 3rd, Aune TM.
J Immunol. 2020 Nov 15;205(10):2606-2617. doi: 10.4049/jimmunol.2000384. Epub 2020 Oct 12.
PMID: 33046502


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Rachel Bonami, PhD


T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Bonami RH, Nyhoff LE, McNitt DH, Hulbert C, Felton JL, Kendall PL, Thomas JW.
J Immunol. 2020 Dec 15;205(12):3263-3276. doi: 10.4049/jimmunol.1900464. Epub 2020 Nov 16.
PMID: 33199538

Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.
Young-Glazer J, Cisneros A 3rd, Wilfong EM, Smith SA, Crofford LJ, Bonami RH.
Arthritis Res Ther. 2021 Jan 19;23(1):33. doi: 10.1186/s13075-020-02412-8.
PMID: 33468230 

High-Throughput Detection of Autoantigen-Specific B Cells Among Distinct Functional Subsets in Autoimmune Donors.
Joosse BA, Jackson JH, Cisneros A, Santhin AB, Smith SA, Moore DJ, Crofford LJ, Wilfong EM, Bonami RH.
Front Immunol. 2021 May 24;12:685718. doi: 10.3389/fimmu.2021.685718. eCollection 2021.
PMID: 34234784 

Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine.
Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker L, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM.
bioRxiv. 2021 Jul 28:2021.07.28.453981. doi: 10.1101/2021.07.28.453981. Preprint.
PMID: 34341788
 

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Mark Boothby, MD, PhD


Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.
Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC,
Cook RS, Boothby MR, Chen J.
J Clin Invest. 2021 Feb 15;131(4):e140100. doi: 10.1172/JCI140100.
PMID: 33320840

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S,
Cook R, Boothby M, Chen J.
JCI Insight. 2020 Aug 6;5(15):e139237. doi: 10.1172/jci.insight.139237.
PMID: 32759497 

Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry.
Jones MA, Cho SH, Patterson NH, Van de Plas R, Spraggins JM, Boothby MR, Caprioli RM.
Anal Chem. 2020 May 19;92(10):7079-7086. doi: 10.1021/acs.analchem.0c00446. Epub 2020 May 6.
PMID: 32298091 

AMPKα1 in B Cells Dampens Primary Antibody Responses yet Promotes Mitochondrial Homeostasis and Persistence of B Cell Memory.
Brookens SK, Cho SH, Basso PJ, Boothby MR.
J Immunol. 2020 Dec 1;205(11):3011-3022. doi: 10.4049/jimmunol.1901474. Epub 2020 Nov 4.
PMID: 33148712

AMPK Metabolism in the B Lineage Modulates Humoral Responses.
Brookens SK, Boothby MR.
Immunometabolism. 2021;3(2):e210011. doi: 10.20900/immunometab20210011. Epub 2021 Feb 12.
PMID: 33717606 


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Dana Brantley-Sieders, PhD

 

EphA2 Is a Clinically Relevant Target for Breast Cancer Bone Metastatic Disease.
Vaught DB, Merkel AR, Lynch CC, Edwards J, Tantawy MN, Hilliard T, Wang S, Peterson T, Johnson RW, Sterling JA, Brantley-Sieders D.
JBMR Plus. 2021 Mar 9;5(4):e10465. doi: 10.1002/jbm4.10465. eCollection 2021 Apr.
PMID: 33869989

Oncogenic functions and therapeutic targeting of EphA2 in cancer.
Wilson K, Shiuan E, Brantley-Sieders DM.
Oncogene. 2021 Apr;40(14):2483-2495. doi: 10.1038/s41388-021-01714-8. Epub 2021 Mar 8.
PMID: 33686241

Host deficiency in ephrin-A1 inhibits breast cancer metastasis.
Shiuan E, Inala A, Wang S, Song W, Youngblood V, Chen J, Brantley-Sieders DM.
F1000Res. 2020 Mar 30;9:217. doi: 10.12688/f1000research.22689.2. eCollection 2020.
PMID: 32399207 

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J.
JCI Insight. 2020 Aug 6;5(15):e139237. doi: 10.1172/jci.insight.139237.
PMID: 32759497 

Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer.
Song W, Kim LC, Han W, Hou Y, Edwards DN, Wang S, Blackwell TS, Cheng F, Brantley-Sieders DM, Chen J.
Mol Cancer Res. 2020 Nov;18(11):1735-1743. doi: 10.1158/1541-7786.MCR-20-0075. Epub 2020 Aug 4.
PMID: 32753469


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Jin Chen, MD, PhD


Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.
Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC,
Cook RS, Boothby MR, Chen J.
J Clin Invest. 2021 Feb 15;131(4):e140100. doi: 10.1172/JCI140100.
PMID: 33320840 

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity
Shan Wang,Ariel Raybuck, Eileen Shiuan, Sung Hoon Cho, Qingfei Wang, Dana M. Brantley-Sieders, Deanna Edwards, Margaret M. Allaman, James Nathan, Keith T. Wilson, David DeNardo, Siyuan Zhang, Rebecca Cook, Mark Boothby, and Jin Chen
JCI Insight. 2020;5(15):e139237. https://doi.org/10.1172/jci.insight.139237.

HIF1α or HIF2α: Enhancing CD8+ T-cell Fitness for Antitumor Immunity.
Chen J.
Cancer Immunol Res. 2021 Apr;9(4):364. doi: 10.1158/2326-6066.CIR-21-0114.
PMID: 34003767

RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1.
Kim LC, Rhee CH, Chen J.
Mol Cancer Res. 2020 Nov;18(11):1675-1684. doi: 10.1158/1541-7786.MCR-20-0262. Epub 2020 Aug 14.
PMID: 32801163

Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer.
Song W, Kim LC, Han W, Hou Y, Edwards DN, Wang S, Blackwell TS, Cheng F, Brantley-Sieders DM, Chen J.
Mol Cancer Res. 2020 Nov;18(11):1735-1743. doi: 10.1158/1541-7786.MCR-20-0075. Epub 2020 Aug 4.
PMID: 32753469 


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Cecilia Chung, MD, MPH


Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
Chaugai S, Dickson AL, Shuey MM, Feng Q, Barker KA, Wei WQ, Luther JM, Stein CM, Chung CP.
Clin Pharmacol Ther. 2019 Mar;105(3):703-709. doi: 10.1002/cpt.1233. Epub 2018 Oct 18.
PMID: 30223305

Comparative out-of-hospital mortality of long-acting opioids prescribed for non-cancer pain: A retrospective cohort study.
Chung CP, Dupont WD, Murray KT, Hall K, Stein CM, Ray WA.
Pharmacoepidemiol Drug Saf. 2019 Jan;28(1):48-53. doi: 10.1002/pds.4619. Epub 2018 Jul 12.
PMID: 30003613 

Individual short-acting opioids and the risk of opioid-related adverse events in adolescents.
Chung CP, Callahan ST, Cooper WO, Dupont WD, Murray KT, Franklin AD, Hall K, Dudley JA, Stein CM, Ray WA.
Pharmacoepidemiol Drug Saf. 2019 Nov;28(11):1448-1456. doi: 10.1002/pds.4872. Epub 2019 Aug 16.
PMID: 31418512

Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.
Anandi P, Dickson AL, Feng Q, Wei WQ, Dupont WD, Plummer D, Liu G, Octaria R, Barker KA, Kawai VK, Birdwell K, Cox NJ, Hung A, Stein CM, Chung CP.
Pharmacogenomics J. 2020 Oct;20(5):736-745. doi: 10.1038/s41397-020-0163-4. Epub 2020 Feb 14.
PMID: 32054992

CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice.
Carranza-Leon D, Dickson AL, Gaedigk A, Stein CM, Chung CP.
Pharmacogenomics J. 2021 Aug;21(4):484-490. doi: 10.1038/s41397-021-00226-8. Epub 2021 Mar 9.
PMID: 33750887


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Paras Karmacharya, MD, MS


The Epidemiology of Psoriatic Arthritis over 5 Decades: A Population-Based Study.
Karmacharya P, Crowson CS, Bekele D, Achenbach SJ, Davis JM 3rd, Ogdie A, Duarte-García A, Ernste FC,
Maradit-Kremers H, Tollefson MM, Wright K.
Arthritis Rheumatol. 2021 Mar 28.
PMID: 33779070 

Diagnostic Delay in Psoriatic Arthritis: A Population Based Study.
Karmacharya P, Wright K, Achenbach SJ, Bekele D, Crowson CS, Ogdie A, Duarte-García A, Ernste FC, Tollefson MM, Davis JM 3rd. 
J Rheumatol. 2021 Feb 15:jrheum.201199.
PMID: 33589556

The Effect of Therapy on Radiographic Progression in Axial Spondyloarthritis: A Systematic Review and Meta-Analysis.
Karmacharya P, Duarte-Garcia A, Dubreuil M, Murad MH, Shahukhal R, Shrestha P, Myasoedova E, Crowson CS, Wright K, Davis JM 3rd. 
Arthritis Rheumatol. 2020 Jan 20. [Epub ahead of print] Review.
PMID: 31960614 

Effects of Therapies on Cardiovascular Events in Ankylosing Spondylitis: A Systematic Review and Meta-Analysis. 
Karmacharya P, Shahukhal R, Crowson CS, Murad MH, Davis JM 3rd, Shrestha P, Bekele D, Wright K, Chakradhar R, Dubreuil M.
Rheumatol Ther. 2020 Dec;7(4):993-1009. Epub 2020 Nov 10.
PMID: 33170493 

Trends in hospitalizations for vertebral compression fracture in ankylosing spondylitis: data from the National Inpatient Sample 2000-2014. 
Dhital R, Oke I, Donato A, Paudel A, Poudel DR, Paudel P, Karmacharya P. 
Clin Rheumatol. 2021 Jul 5.
PMID: 34224028


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Michelle Ormseth, MD, MSCI


Circulating microbial small RNAs are altered in patients with rheumatoid arthritis.
Ormseth MJ, Wu Q, Zhao S, Allen RM, Solus J, Sheng Q, Guo Y, Ye F, Ramirez-Solano M, Bridges SL, Curtis JR, Vickers K, Stein CM.
Ann Rheum Dis. 2020 Dec;79(12):1557-1564. doi: 10.1136/annrheumdis-2020-217589. Epub 2020 Sep 21.
PMID: 32958509

Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls.
Ormseth MJ, Solus JF, Sheng Q, Ye F, Wu Q, Guo Y, Oeser AM, Allen RM, Vickers KC, Stein CM.
J Rheumatol. 2020 Feb;47(2):188-196. doi: 10.3899/jrheum.181029. Epub 2019 May 15.
PMID: 31092710 

The Endogenous Plasma Small RNAome of Rheumatoid Arthritis.
Ormseth MJ, Solus JF, Sheng Q, Ye F, Song H, Wu Q, Guo Y, Oeser AM, Allen RM, Vickers KC, Stein CM.
ACR Open Rheumatol. 2020 Feb;2(2):97-105. doi: 10.1002/acr2.11098. Epub 2020 Jan 8.
PMID: 31913579 

Tissue sodium content in patients with systemic lupus erythematosus: association with disease activity and markers of inflammation.
Carranza-León DA, Oeser A, Marton A, Wang P, Gore JC, Titze J, Stein CM, Chung CP, Ormseth MJ.
Lupus. 2020 Apr;29(5):455-462. doi: 10.1177/0961203320908934. Epub 2020 Feb 18.
PMID: 32070186

The noncoding RNA interactome in joint health and disease.
Shabana AA, Peffers M, Ormseth MJ, Jurisica I, Kapoor M. 
Nat Rev Rheumatol. Accepted.
(This one is not available on pubmed yet, but is coming soon)


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