Tom Aune, PhD 

Methotrexate and its mechanisms of action in inflammatory arthritis.
Cronstein BN, Aune TM.
Nat Rev Rheumatol. 2020 Mar;16(3):145-154. doi: 10.1038/s41584-020-0373-9. Epub 2020 Feb 17.
PMID: 32066940

Immunoprecipitation of DNA:RNA Hybrids Using the S9.6 Antibody.
Gibbons HR, Aune TM.
Methods Mol Biol. 2020;2161:195-207. doi: 10.1007/978-1-0716-0680-3_14.
PMID: 32681514

A simplified method to produce mRNAs and functional proteins from synthetic double-stranded DNA templates.
Tossberg JT, Esmond TM, Aune TM.
Biotechniques. 2020 Oct;69(4):281-288. doi: 10.2144/btn-2020-0037. Epub 2020 Aug 20.
PMID: 32815735

Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production.
Gibbons HR, Mi DJ, Farley VM, Esmond T, Kaood MB, Aune TM.
Sci Rep. 2019 Jul 16;9(1):10280. doi: 10.1038/s41598-019-46516-x.
PMID: 31311960 

Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds)RNAs Is Markedly Decreased in Multiple Sclerosis and Unedited Alu dsRNAs Are Potent Activators of Proinflammatory Transcriptional Responses.
Tossberg JT, Heinrich RM, Farley VM, Crooke PS 3rd, Aune TM.
J Immunol. 2020 Nov 15;205(10):2606-2617. doi: 10.4049/jimmunol.2000384. Epub 2020 Oct 12.
PMID: 33046502

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Rachel Bonami, PhD

T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Bonami RH, Nyhoff LE, McNitt DH, Hulbert C, Felton JL, Kendall PL, Thomas JW.
J Immunol. 2020 Dec 15;205(12):3263-3276. doi: 10.4049/jimmunol.1900464. Epub 2020 Nov 16.
PMID: 33199538

Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.
Young-Glazer J, Cisneros A 3rd, Wilfong EM, Smith SA, Crofford LJ, Bonami RH.
Arthritis Res Ther. 2021 Jan 19;23(1):33. doi: 10.1186/s13075-020-02412-8.
PMID: 33468230 

High-Throughput Detection of Autoantigen-Specific B Cells Among Distinct Functional Subsets in Autoimmune Donors.
Joosse BA, Jackson JH, Cisneros A, Santhin AB, Smith SA, Moore DJ, Crofford LJ, Wilfong EM, Bonami RH.
Front Immunol. 2021 May 24;12:685718. doi: 10.3389/fimmu.2021.685718. eCollection 2021.
PMID: 34234784 

Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine.
Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker L, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM.
bioRxiv. 2021 Jul 28:2021.07.28.453981. doi: 10.1101/2021.07.28.453981. Preprint.
PMID: 34341788

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Mark Boothby, MD, PhD

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.
Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC,
Cook RS, Boothby MR, Chen J.
J Clin Invest. 2021 Feb 15;131(4):e140100. doi: 10.1172/JCI140100.
PMID: 33320840

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S,
Cook R, Boothby M, Chen J.
JCI Insight. 2020 Aug 6;5(15):e139237. doi: 10.1172/jci.insight.139237.
PMID: 32759497 

Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry.
Jones MA, Cho SH, Patterson NH, Van de Plas R, Spraggins JM, Boothby MR, Caprioli RM.
Anal Chem. 2020 May 19;92(10):7079-7086. doi: 10.1021/acs.analchem.0c00446. Epub 2020 May 6.
PMID: 32298091 

AMPKα1 in B Cells Dampens Primary Antibody Responses yet Promotes Mitochondrial Homeostasis and Persistence of B Cell Memory.
Brookens SK, Cho SH, Basso PJ, Boothby MR.
J Immunol. 2020 Dec 1;205(11):3011-3022. doi: 10.4049/jimmunol.1901474. Epub 2020 Nov 4.
PMID: 33148712

AMPK Metabolism in the B Lineage Modulates Humoral Responses.
Brookens SK, Boothby MR.
Immunometabolism. 2021;3(2):e210011. doi: 10.20900/immunometab20210011. Epub 2021 Feb 12.
PMID: 33717606 

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Jin Chen, MD, PhD

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.
Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC,
Cook RS, Boothby MR, Chen J.
J Clin Invest. 2021 Feb 15;131(4):e140100. doi: 10.1172/JCI140100.
PMID: 33320840 

Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity
Shan Wang,Ariel Raybuck, Eileen Shiuan, Sung Hoon Cho, Qingfei Wang, Dana M. Brantley-Sieders, Deanna Edwards, Margaret M. Allaman, James Nathan, Keith T. Wilson, David DeNardo, Siyuan Zhang, Rebecca Cook, Mark Boothby, and Jin Chen
JCI Insight. 2020;5(15):e139237.

HIF1α or HIF2α: Enhancing CD8+ T-cell Fitness for Antitumor Immunity.
Chen J.
Cancer Immunol Res. 2021 Apr;9(4):364. doi: 10.1158/2326-6066.CIR-21-0114.
PMID: 34003767

RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1.
Kim LC, Rhee CH, Chen J.
Mol Cancer Res. 2020 Nov;18(11):1675-1684. doi: 10.1158/1541-7786.MCR-20-0262. Epub 2020 Aug 14.
PMID: 32801163

Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer.
Song W, Kim LC, Han W, Hou Y, Edwards DN, Wang S, Blackwell TS, Cheng F, Brantley-Sieders DM, Chen J.
Mol Cancer Res. 2020 Nov;18(11):1735-1743. doi: 10.1158/1541-7786.MCR-20-0075. Epub 2020 Aug 4.
PMID: 32753469 

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Cecilia Chung, MD, MPH

Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
Chaugai S, Dickson AL, Shuey MM, Feng Q, Barker KA, Wei WQ, Luther JM, Stein CM, Chung CP.
Clin Pharmacol Ther. 2019 Mar;105(3):703-709. doi: 10.1002/cpt.1233. Epub 2018 Oct 18.
PMID: 30223305

Comparative out-of-hospital mortality of long-acting opioids prescribed for non-cancer pain: A retrospective cohort study.
Chung CP, Dupont WD, Murray KT, Hall K, Stein CM, Ray WA.
Pharmacoepidemiol Drug Saf. 2019 Jan;28(1):48-53. doi: 10.1002/pds.4619. Epub 2018 Jul 12.
PMID: 30003613 

Individual short-acting opioids and the risk of opioid-related adverse events in adolescents.
Chung CP, Callahan ST, Cooper WO, Dupont WD, Murray KT, Franklin AD, Hall K, Dudley JA, Stein CM, Ray WA.
Pharmacoepidemiol Drug Saf. 2019 Nov;28(11):1448-1456. doi: 10.1002/pds.4872. Epub 2019 Aug 16.
PMID: 31418512

Combining clinical and candidate gene data into a risk score for azathioprine-associated leukopenia in routine clinical practice.
Anandi P, Dickson AL, Feng Q, Wei WQ, Dupont WD, Plummer D, Liu G, Octaria R, Barker KA, Kawai VK, Birdwell K, Cox NJ, Hung A, Stein CM, Chung CP.
Pharmacogenomics J. 2020 Oct;20(5):736-745. doi: 10.1038/s41397-020-0163-4. Epub 2020 Feb 14.
PMID: 32054992

CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice.
Carranza-Leon D, Dickson AL, Gaedigk A, Stein CM, Chung CP.
Pharmacogenomics J. 2021 Aug;21(4):484-490. doi: 10.1038/s41397-021-00226-8. Epub 2021 Mar 9.
PMID: 33750887

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Deanna Edwards, PhD


Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple- negative breast cancer.
Edwards, D. N., Ngwa, V. M., Raybuck, A. L., Wang, S., Hwang, Y., Kim, L. C., Cho, S. H., Paik, Y., Wang, Q., Zhang, S., Manning, H. C., Rathmell, J. C., Cook, R. S., Boothby, M. R., Chen, J.
J Clin Invest. 131(4):e140100, 2021. doi: 10.1172/JCI140100. 
PMCID: PMC7880417

Selective inhibition of mTORC1 in tumor blood vessels increases anti-tumor immunity.
Wang, S., Raybuck, A., Shiuan, E., Cho S. H., Wang, Q., Brantley-Sieders, D., Edwards, D., Allaman, M., Nathan, J., Wilson, K.T., DeNardo, D., Zhang, S., Cook, R., Boothby, M., Chen, J.
JCI Insight. 5(15):e139237, 2020. doi: 10.1172/jci.insight.139237. 
PMCID: PMC7455083

Regulation of anti-tumor immunity by microenvironmental metabolism.
Ngwa, V. M, Edwards, D. N., Philip, M., Chen, J.
Cancer Res. 79(16):4003-4008, 2019. doi: 10.1158/0008- 5472.CAN-19-0617. 
PMCID: PMC6697577

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. 
Edwards, D. N., Ngwa, V. M., Wang, S., Shiuan, E., Brantley-Sieders, D. M., Kim, L. C., Reynolds, A. B., Chen, J.
Sci Signal. 10(508):eaan4667, 2017. doi: 10.1126/scisignal.aan4667. 
PMCID: PMC5819349

The ephrin-A1/EPHA2 signaling axis regulates glutamine metabolism in HER2-positive breast cancer.
Youngblood, V. M., Kim, L. C., Edwards, D. N., Hwang, Y., Santapuram, P. R., Stirdivant, S. M., Lu, P., Ye, F., Brantley-Sieders, D. M., Chen, J. Cancer Res. 76:1825-1836, 2016. doi: 10.1158/0008- 5472.CAN-15-0847. 
PMCID: PMC4873477


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Tracy Frech, MD, MS


Clinical Bedside Tools to Assess Systemic Sclerosis Vasculopathy: Can Digital Thermal Monitoring and Sublingual Microscopy Identify Patients With Digital Ulcers?
Frech TM, Ou Z, Presson AP.
J Rheumatol. 2021 Oct;48(10):1566-1568. doi: 10.3899/jrheum.201234. Epub 2021 Feb 1.
PMID: 33526620

Implications of endothelial shear stress on systemic sclerosis vasculopathy and treatment
Frech TM, Machin DR, Murtaugh MA, Stoddard GJ, Bloom SI, Phibbs JV, Donato AJ.Clin Exp Rheumatol. 2018 Jul-Aug;36 Suppl 113(4):175-182. Epub 2018 Sep 20.
PMID: 30277867 

Vascular Leaking, a Pivotal and Early Pathogenetic Event in Systemic Sclerosis: Should the Door Be Closed?
Bruni C, Frech T, Manetti M, Rossi FW, Furst DE, De Paulis A, Rivellese F, Guiducci S, Matucci-Cerinic M, Bellando-Randone S.
Front Immunol. 2018 Sep 7;9:2045. doi: 10.3389/fimmu.2018.02045. eCollection 2018.
PMID: 30245695

Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction
Frech T, Walker AE, Barrett-O'Keefe Z, Hopkins PN, Richardson RS, Wray DW, Donato AJ.
Clin Rheumatol. 2015 May;34(5):905-13. doi: 10.1007/s10067-014-2834-5. Epub 2014 Dec 16.
PMID: 25511849

Heritability of vasculopathy, autoimmune disease, and fibrosis in systemic sclerosis: a population-based study
Frech T, Khanna D, Markewitz B, Mineau G, Pimentel R, Sawitzke A.
Arthritis Rheum. 2010 Jul;62(7):2109-16. doi: 10.1002/art.27469.
PMID: 20506251 


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Paras Karmacharya, MD, MS

The Epidemiology of Psoriatic Arthritis over 5 Decades: A Population-Based Study.
Karmacharya P, Crowson CS, Bekele D, Achenbach SJ, Davis JM 3rd, Ogdie A, Duarte-García A, Ernste FC,
Maradit-Kremers H, Tollefson MM, Wright K.
Arthritis Rheumatol. 2021 Mar 28.
PMID: 33779070 

Diagnostic Delay in Psoriatic Arthritis: A Population Based Study.
Karmacharya P, Wright K, Achenbach SJ, Bekele D, Crowson CS, Ogdie A, Duarte-García A, Ernste FC, Tollefson MM, Davis JM 3rd. 
J Rheumatol. 2021 Feb 15:jrheum.201199.
PMID: 33589556

The Effect of Therapy on Radiographic Progression in Axial Spondyloarthritis: A Systematic Review and Meta-Analysis.
Karmacharya P, Duarte-Garcia A, Dubreuil M, Murad MH, Shahukhal R, Shrestha P, Myasoedova E, Crowson CS, Wright K, Davis JM 3rd. 
Arthritis Rheumatol. 2020 Jan 20. [Epub ahead of print] Review.
PMID: 31960614 

Effects of Therapies on Cardiovascular Events in Ankylosing Spondylitis: A Systematic Review and Meta-Analysis. 
Karmacharya P, Shahukhal R, Crowson CS, Murad MH, Davis JM 3rd, Shrestha P, Bekele D, Wright K, Chakradhar R, Dubreuil M.
Rheumatol Ther. 2020 Dec;7(4):993-1009. Epub 2020 Nov 10.
PMID: 33170493 

Trends in hospitalizations for vertebral compression fracture in ankylosing spondylitis: data from the National Inpatient Sample 2000-2014. 
Dhital R, Oke I, Donato A, Paudel A, Poudel DR, Paudel P, Karmacharya P. 
Clin Rheumatol. 2021 Jul 5.
PMID: 34224028

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Michelle Ormseth, MD, MSCI

Circulating microbial small RNAs are altered in patients with rheumatoid arthritis.
Ormseth MJ, Wu Q, Zhao S, Allen RM, Solus J, Sheng Q, Guo Y, Ye F, Ramirez-Solano M, Bridges SL, Curtis JR, Vickers K, Stein CM.
Ann Rheum Dis. 2020 Dec;79(12):1557-1564. doi: 10.1136/annrheumdis-2020-217589. Epub 2020 Sep 21.
PMID: 32958509

Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls.
Ormseth MJ, Solus JF, Sheng Q, Ye F, Wu Q, Guo Y, Oeser AM, Allen RM, Vickers KC, Stein CM.
J Rheumatol. 2020 Feb;47(2):188-196. doi: 10.3899/jrheum.181029. Epub 2019 May 15.
PMID: 31092710 

The Endogenous Plasma Small RNAome of Rheumatoid Arthritis.
Ormseth MJ, Solus JF, Sheng Q, Ye F, Song H, Wu Q, Guo Y, Oeser AM, Allen RM, Vickers KC, Stein CM.
ACR Open Rheumatol. 2020 Feb;2(2):97-105. doi: 10.1002/acr2.11098. Epub 2020 Jan 8.
PMID: 31913579 

Tissue sodium content in patients with systemic lupus erythematosus: association with disease activity and markers of inflammation.
Carranza-León DA, Oeser A, Marton A, Wang P, Gore JC, Titze J, Stein CM, Chung CP, Ormseth MJ.
Lupus. 2020 Apr;29(5):455-462. doi: 10.1177/0961203320908934. Epub 2020 Feb 18.
PMID: 32070186

The noncoding RNA interactome in joint health and disease.
Shabana AA, Peffers M, Ormseth MJ, Jurisica I, Kapoor M. 
Nat Rev Rheumatol. Accepted.
(This one is not available on pubmed yet, but is coming soon)

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Jason Springer, MD



Clinical Characteristics of an Internet-Based Cohort of Patient-Reported Diagnosis of Granulomatosis With Polyangiitis and Microscopic Polyangiitis: Observational Study.
Springer JM, Kermani TA, Sreih A, Shaw DG, Young K, Burroughs CM, Merkel PA.
J Med Internet Res. 2020 Jul 20;22(7):e17231. doi: 10.2196/17231.
PMID: 32459634

Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review and Meta-Analysis of Test Accuracy and Benefits and Harms of Common Treatments.
Springer JM, Kalot MA, Husainat NM, Byram KW, Dua AB, James KE, Chang Lin Y, Turgunbaev M, Villa-Forte A, Abril A, Langford CA, Maz M, Chung SA, Mustafa RA.
ACR Open Rheumatol. 2021 Feb;3(2):101-110. doi: 10.1002/acr2.11194. Epub 2021 Jan 29.
PMID: 33512787

Granulomatosis With Polyangiitis and Microscopic Polyangiitis: A Systematic Review and Meta-Analysis of Benefits and Harms of Common Treatments.
Springer JM, Kalot MA, Husainat NM, Byram KW, Dua AB, James KE, Chang Lin Y, Turgunbaev M, Villa-Forte A, Abril A, Langford C, Maz M, Chung SA, Mustafa RA.
ACR Open Rheumatol. 2021 Mar;3(3):196-205. doi: 10.1002/acr2.11230. Epub 2021 Feb 16.
PMID: 33590973

Dose-dependent Pharmacological Response to Rituximab in the Treatment of Antineutrophil Cytoplasmic Antibody-associated Vasculitis.
Springer JM, Funk RS.
J Rheumatol. 2021 Nov;48(11):1718-1724. doi: 10.3899/jrheum.210361. Epub 2021 Aug 1.
PMID: 34334366

Defining a Therapeutic Window for Rituximab Maintenance Therapy in ANCA-Associated Vasculitis: A Longitudinal Observational Study.
Springer JM, Funk RS.
J Clin Rheumatol. 2021 Aug 1;27(5):215-217. doi: 10.1097/RHU.0000000000001688.
PMID: 33337800


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S. Bobo Tanner, IV, MD


Use of Bone Health Evaluation in Orthopedic Surgery: The 2019 ISCD Official Positions.
Anderson PA, Morgan SL, Kreuger D, Zapalowski C, Tanner B, Jeray KJ, Krohn KD, Lane JP, Yeap SS, Shuhart CR0, Shepherd J.
J Clin Densitom. 2019 Aug 16. pii: S1094-6950(19)30130-1. doi: 10.1016/j.jocd.2019.07.013.
PMID: 31519473

Clinician's Guide to Prevention and Treatment of Osteoporosis.
Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, Lindsay R.
Osteoporos Int. 2014 Oct; 25(10):2359-81. doi: 10.1007/s00198-014-2794-2. Epub 2014 Aug 15.
PMID: 25182228

Consensus of official position of IOF/ISCD FRAX initiatives in Asia-Pacific region.
Wu CH, McCloskey EV, Lee JK, Itabashi A, Prince R, Yu W, Li-Yu J, Chionh SB, Zhao Y, Shin CS, Gunawan T, Tsai KS, Chieng PU, Changlai SP, Chan DC, Chen JF, Tanner SB, Hans DB, Kanis JA, Chang YF, Sun ZJ, Yang RS; Asia Pacific Panel of ISCD.
J Clin Densitom. 2014 Jan-Mar;17(1):150-5. doi: 10.1016/j.jocd.2013.06.002. Epub 2013 Jul 31.
PMID: 23916756

Evaluation of a Vitamin D Screening and Treatment Protocol Using a Seasonal Calculator in Athletes.
Hollabaugh WL, Meirick PJ, Matarazzo CP, Burston AM, Camery ME, Ferrill-Moseley KA, Bley JA, Pennings JS, Fitch RW, Tanner SB, Karpinos AR.
Curr Sports Med Rep. 2022 Feb 1;21(2):53-62. doi: 10.1249/JSR.0000000000000934.
PMID: 35120051

Official Positions for FRAX® clinical regarding rheumatoid arthritis from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®.
Broy SB, Tanner SB; FRAX(®)Position Development Conference Members.
J Clin Densitom. 2011 Jul-Sep;14(3):184-9.
PMID: 21810523


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