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User Detail

David Harrison, MD

Professor of Medicine

Division of Genetic Medicine and Clinical Pharmacology

Betty and Jack Bailey Chair in Cardiology

David Harrison
Professional Bio
David G. Harrison, MD, FACC, FAHA, Professor of Medicine in the Department of Medicine at Vanderbilt University Medical Center. His research laboratory has been focused on understanding how inflammation, and in particular, the adaptive immune response contributes to hypertension. His lab found that T cells are essential for the development of hypertension and has shown that various hypertensive stimuli, including angiotensin II, norepinephrine and DOCA-salt cause activation of T cells and leads to their accumulation in the perivascular fat and kidneys. The data indicates that T cell-derived cytokines such as IL-17 and TNF-a enhance vasoconstriction and sodium retention, leading to the hypertensive phenotype. Central signals derived from the circumventricular organs contribute to T cell activation, and manipulation of signals from this region affect T cell activation and the eventual elevation in blood pressure caused by angiotensin II. Dr. Harrison's lab is studying mechanisms involved in T cell activation in response to hypertensive stimuli. They have recently shown that gamma-ketoaldehydes, or isolevuglandins (isoLGs) adduct to proteins in hypertensive mice and humans, and that these are immunogenic. These modified proteins seem to act as 'auto-antigens' that promote dendritic cell and ultimately T cell activation in hypertension. Recent studies have defined characteristics of class I major histocompatibility complexes that accommodate isoLG adducted peptides, leading to identification of several candidate renal derived peptides that act as antigens in hypertension.
Publications
View Publications

Education

MD - Oklahoma State University, 1974

Internship - Duke University, 1975

Residency - Duke University, 1977

Fellowship - CA - University of Iowa, 1982

Contact

Email 
Kimryn.Rathmell@Vumc.Org 
Address 
777 Preston Research Building 
2220 Pierce Ave 
Nashville, TN 37232-6307

Submitted by admin on Thu, 06/01/2023 - 04:28

1161 21st Ave S
Nashville, TN 37232

(615) 322-5000

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