Professional Bio
Jack Jacek Hawiger, MD, PhD, is a Distinguished Professor of Medicine and Louis McGavock Chair in Medicine in the Division of Allergy, Pulmonary and Critical Care Medicine within the Department of Medicine at Vanderbilt University Medical Center. He is a Professor of Molecular Physiology and Biophysics within the Department of Molecular Physiology and Biophysics at Vanderbilt University School of Medicine and a Research Health Scientist in Nashville VA Medical Center.
He is a physician-scientist conducting research in the field of inflammation and vascular biology. His ongoing research is focused on the mechanism of inflammation by highlighting the cell's nucleus as the command center of inflammatory response underlying the most of human diseases caused by allergic, autoimmune, metabolic, microbial, and physical insults. He pioneered with his colleagues a new approach to the control of inflammation through intracellular therapy with the Nuclear Transport Checkpoint inhibitors or with physiologic proteins known as suppressors of cytokine signaling.
Dr. Hawiger and his team developed a new method of non-invasive intracellular delivery of cell-penetrating peptides and proteins for anti-inflammatory therapy. One of these therapeutics is in the ongoing Phase 1/2 Clinical Trial for Atopic Dermatitis aka eczema (NCT04313400). Prior to these studies, Dr. Hawiger established the molecular mechanism of binding of human coagulation protein, fibrinogen, to staphylococci and human platelets, which led to a new test for detection of fibrin degradation products in patients with Disseminated intravascular Coagulation. He introduced fibrinogen-derived peptides as the blockers of human platelet integrins, the target of anti-thrombotic therapy. He is an inventor or co-inventor of 31 patents issued or pending in the US and abroad.
Publications
Education
Internship - Universite Paris-Sorbonne (Paris IV), 1962
MD - Jagiellonian University Cracow, 1962
Residency - Jagiellonian University Cracow, 1963
PhD - National Institutes of Pub Health, 1967
Fellowship - ID - Vanderbilt University, 1969
Contact
Email
Kimryn.Rathmell@Vumc.Org
Address
777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307