Professional Bio
Patricia Yancey, PhD, is a Research Assistant Professor in the Division of Cardiovascular Medicine in the Department of Medicine at Vanderbilt University Medical Center.
Her background is in atherosclerosis research with an emphasis on lipoprotein metabolism and macrophage cholesterol homeostasis. Her earlier studies addressed the importance of protein amphipathic helical content in reducing macrophage cholesterol burden. She further established that the macrophage trafficking of acetylated versus oxidized LDL differed resulting in impaired availability of oxidized LDL cholesterol for efflux.
As an assistant member at Joseph Stokes Research Institute at Children's Hospital of Philadelphia, Dr. Yancey's research defined what cholesterol acceptor properties were relevant to mobilizing cholesterol via SR-BI and ABCA1 pathways. Since joining the faculty at Vanderbilt, her research established a cooperative interaction of exogenous apoAI and endogenous apoE in maximizing macrophage cholesterol transport via ABCA1. Her research also showed that macrophage SR-BI and apoE protect against atherosclerosis by preventing the sequestration of lysosomal cholesterol. She has extended her research efforts to focus on the role of LRP1 and SR-BI in macrophage inflammation, apoptosis, and efferocytosis.
Recent research has focused on the impact of Isolevuglandins and malondialdehyde adducts on HDL cholesterol acceptor, anti-inflammatory, and anti-oxidant functions. Dr. Yancey and her team recently demonstrated that reactive dicarbonyl scavenging with 2-hydroxybenzylamine reduced atherosclerosis and improved HDL cholesterol efflux and anti-inflammatory functions.
Education
PhD - Wake Forest University, 1993
Fellowship - Biochemistry - Medical College of Pennsylvania and Hahnemann University, 1995
Fellowship - Pathology - Wake Forest University, 1999
Contact
Email
Kimryn.Rathmell@Vumc.Org
Address
777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307