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User Detail

Raymond Blind, PhD

Associate Professor of Medicine

Division of Diabetes, Endocrinology and Metabolism
Raymond Blind
Professional Bio
Raymond Blind, PhD, is an Associate Professor of Medicine in the Division of Diabetes, Endocrinology and Metabolism, Department of Medicine at Vanderbilt University Medical Center. The Blind Lab is affiliated with the Vanderbilt Center for Structural Biology, the Vanderbilt Institute of Chemical Biology and the Vanderbilt-Ingram Cancer Center. The lab explores second messenger signaling in the nucleus. Specifically, they seek to understand the structure, function and signaling properties of nuclear inositide lipids and inositol phosphates, asking how these molecules directly participate in controlling gene expression. The Blind Lab uses functional genomics, structural biology and chemical genetics to query how these second messengers operate. They then attempt to apply that information to develop drug discovery platforms, with potential to treat cancer and metabolic diseases. Nuclear inositide signaling is particularly interesting because the nucleus contains unique pools of lipids that do not exist in any membrane structure, but are instead complexed with soluble proteins. The Blind Lab discovered certain pools of nuclear inositides can be directly remodeled by lipid signaling enzymes, with remarkable kinetic properties, providing a new framework to explain how nuclear second messenger signaling works. Current research in the lab is focused on determining what role phosphorylated inositols, phosphoinositide lipids and their signaling enzymes play in chromatin biology, determining how nuclear phosphoinositide complexes are structured, identifying rapid nuclear signaling events using chemical genetics, and understanding how nuclear receptors acquire phospholipid ligands from membranes.
Relevant Links
VICC Profile Blind Lab
Publications
View Publications

Education

PhD - Philosophy - New York University, 2005

Fellowship - Pharmaceutical Chemistry - University of California, San Francisco, 2006

EdD - Cell & Molecular Pharmacology - University of California, San Francisco, 2015

Contact

Email 
Kimryn.Rathmell@Vumc.Org 
Address 
777 Preston Research Building 
2220 Pierce Ave 
Nashville, TN 37232-6307

Submitted by admin on Thu, 06/01/2023 - 04:28

1161 21st Ave S
Nashville, TN 37232

(615) 322-5000

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