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User Detail

Roberto M Vanacore, PhD

Division of Nephrology and Hypertension

Associate Professor of Medicine

Roberto M Vanacore
Professional Bio
Roberto Vanacore, PhD, is an Associate Professor of Medicine in the Division of Nephrology and Hypertension within the Department of Medicine at Vanderbilt University Medical Center. The focus of Dr. Vanacore’s research is the study of extracellular matrix (ECM) proteins, particularly collagen IV and its modifying enzymes, which are involved in life-threatening human diseases such as diabetic nephropathy, vascular disease, Goodpasture disease, and Alport syndrome. Collagen IV forms crosslinked supramolecular scaffolds that are essential for the mechanical stability of basement membranes and act as ligands for integrins influencing cell behaviors such as proliferation, differentiation, and migration. Dr. Vanacore has made important discoveries about the chemistry and pathology of basement membranes, including the discovery and assembly of the novel evolutionary conserved sulfilimine bond (S=N) that crosslinks the carboxyl-terminal NC1 domain of collagen IV, the first of its kind in a biomolecule. More recently, Dr. Vanacore is investigating the role of collagen crosslinking enzyme lysyl oxidase like-2 (LOXL2) in renal fibrosis. These investigations pursue a better understanding of role of these ECM proteins in normal tissue function and development of chronic kidney disease. His lab uses transgenic mouse models of kidney disease in combination with state-of-the-art mass spectrometry-based proteomics and a variety of biochemical, molecular and cell biology techniques.
Publications
View Publications

Education

PhD - Biochemistry and Molecular Biology - University of Kansas, 2005

Fellowship - Nephrology - Vanderbilt University, 2008

Contact

Email 
Kimryn.Rathmell@Vumc.Org 
Address 
777 Preston Research Building 
2220 Pierce Ave 
Nashville, TN 37232-6307

Submitted by admin on Thu, 06/01/2023 - 04:28

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