Professional Bio
Sergey Dikalov, PhD, is a Research Professor of Medicine in the Division of Clinical Pharmacology, Department of Medicine at Vanderbilt University Medical Center.
He previously directed the Free Radicals in Medicine Core lab at Emory University and became an expert in the studies of vascular oxidative stress such as NADPH oxidases, uncoupled endothelial NO synthase, xanthine oxidase and mitochondria. He came to Vanderbilt Medical Center in 2011 as an Associate Professor and Director of Free Radicals in Medicine Core, Division of Clinical Pharmacology where he provided invaluable contribution to Vanderbilt Clinical and basic science research projects.
Dr. Dikalov is a fellow of the American Heart Association (AHA) and serves on AHA committees. He has been an invited speaker locally and nationally at academic institutions and scientific meetings. He has authored over 156 original publications, including 46 as first author. These have appeared in high impact journals in cardiovascular sciences such as Journal of Clinical Investigation, Circulation Research, Hypertension, and Journal of Biological Chemistry.
His major accomplishments include discovery that essential hypertension is linked to mitochondrial dysfunction, overproduction of mitochondrial superoxide and formation of highly reactive oxidative stress products isolevuglandins. He developed mitochondria-targeted superoxide scavenger mitoTEMPO and mitochondrial scavenger of isolevuglandins mito2HOBA which improve mitochondrial function, reduce vascular dysfunction, and diminish hypertension. His work demonstrated pathogenic role of mitochondrial isolevuglandins including Sirt3 inactivation and promoting mitochondrial dysfunction. He demonstrated that mitochondrial cyclophilin D (CypD) has a previously unidentified role in vascular dysfunction and hypertension and supported the therapeutic potential of targeting CypD in this disease.
Dr. Dikalov directs the Free Radical in Medicine Core function and training of graduate students and medical fellows in measurements of oxidative stress using state-of-art methods such as Electron Spin Resonance and HPLC providing indispensable support for oxidative stress studies at Vanderbilt.
Relevant Links
Publications
Education
MS - Novosibirsk State University, 1989
Fellowship - Universitat Frankfurt, 1994
PhD - Institute of Chemical Kinetics and Combustion, 1994
Fellowship - Universitat Frankfurt, 1995
Fellowship - Albert-Ludwigs-Universitat Freiburg, 1997
Fellowship - National Institute of Environmental health Sciences, 2001
Contact
Email
Kimryn.Rathmell@Vumc.Org
Address
777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307