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User Detail

Sergey Dikalov, PhD

Research Professor of Medicine

Division of Genetic Medicine and Clinical Pharmacology
Sergey Dikalov
Professional Bio
Sergey Dikalov, PhD, is a Research Professor of Medicine in the Department of Medicine at Vanderbilt University Medical Center (VUMC). He previously directed the Free Radicals in Medicine Core lab at Emory University and became an expert in the studies of vascular oxidative stress such as NADPH oxidases, uncoupled endothelial NO synthase, xanthine oxidase and mitochondria. He came to VUMC in 2011 as an associate professor and director of Free Radicals in Medicine Core, where he provided invaluable contribution to Vanderbilt clinical and basic science research projects. Dr. Dikalov is a fellow of the American Heart Association (AHA) and serves on AHA committees. He has been an invited speaker locally and nationally at academic institutions and scientific meetings. He has authored over 156 original publications, including 46 as first author. These have appeared in high impact journals in cardiovascular sciences such as Journal of Clinical Investigation, Circulation Research, Hypertension, and Journal of Biological Chemistry. His major accomplishments include discovery that essential hypertension is linked to mitochondrial dysfunction, overproduction of mitochondrial superoxide and formation of highly reactive oxidative stress products isolevuglandins. He developed mitochondria-targeted superoxide scavenger mitoTEMPO and mitochondrial scavenger of isolevuglandins mito2HOBA which improve mitochondrial function, reduce vascular dysfunction, and diminish hypertension. His work demonstrated pathogenic role of mitochondrial isolevuglandins including Sirt3 inactivation and promoting mitochondrial dysfunction. He demonstrated that mitochondrial cyclophilin D (CypD) has a previously unidentified role in vascular dysfunction and hypertension and supported the therapeutic potential of targeting CypD in this disease. Dr. Dikalov directs the Free Radicals in Medicine Core function and training of graduate students and medical fellows in measurements of oxidative stress using state-of-art methods such as Electron Spin Resonance and HPLC providing indispensable support for oxidative stress studies at Vanderbilt.
Publications
View Publications

Education

MS - Novosibirsk State University, 1989

Fellowship - Universitat Frankfurt, 1994

PhD - Institute of Chemical Kinetics and Combustion, 1994

Fellowship - Universitat Frankfurt, 1995

Fellowship - Albert-Ludwigs-Universitat Freiburg, 1997

Fellowship - National Institute of Environmental health Sciences, 2001

Contact

Email 
Kimryn.Rathmell@Vumc.Org 
Address 
777 Preston Research Building 
2220 Pierce Ave 
Nashville, TN 37232-6307

Submitted by admin on Thu, 06/01/2023 - 04:28

1161 21st Ave S
Nashville, TN 37232

(615) 322-5000

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