Professional Bio
Simon Mallal, MBBS, is a physician-scientist and holds the Major E.B. Stahlman Chair in Infectious Diseases and Inflammation at Vanderbilt University Medical Center. He directs the Tennessee Center for AIDS Research, the Center for Translational Immunology and Infectious Diseases and Vanderbilt Technologies for Advanced Genomics. In addition to his primary appointment in the Department of Medicine, Dr. Mallal is also a Professor of Biomedical Informatics and a Professor of Pathology, Microbiology, and Immunology.
He trained in Internal Medicine, Clinical Immunology and Allergy and Pathology and completed a postdoctoral fellowship in Infectious Diseases at Johns Hopkins Medical School. He developed HIV/AIDS services and one of the world's first population-based electronic medical record systems to support HIV care and research in Western Australia.
Dr. Mallal has undertaken clinical practice management-altering research throughout his career, efforts that have informed and directed his basic science research. This has had impacts over time in the domains of reproductive endocrinology, genetic disease association studies, immune restoration disease in HIV, improved efficacy of antiretroviral therapy, mitochondrial toxicity and metabolic complications of antiretroviral therapy, use of pharmacogenetic tests to avoid drug hypersensitivity, and HIV and Hepatitis C adaptation to HLA restricted immune responses to support vaccine immunogen design and potential eradication approaches.
His group discovered the association between HLA-B*5701 and abacavir hypersensitivity in 2002, and he and his colleagues championed the international collaborative efforts to guide pharmacogenetic screening through the T1 to T4 phases of translation. The impact on clinical and healthcare practice and policy in these domains has been important, as has the development of new multidisciplinary, immunogenomic and multi-omic capacities and approaches to translational medicine.
He is a member of the Association of American Physicians and a Fellow of the American Association for the Advancement of Science and has received several awards recognizing his worldwide clinical and scientific impact.
Relevant Links
Publications
Education
MBBS - University of Western Australia, 1983
Fellowship - Royal Australasian College of Physicians, 1991
Fellowship - Royal College of Pathologists of Australasia, 1992
Fellowship - Post-doctoral fellowship in ID - Johns Hopkins University, 1994
Contact
Email
Kimryn.Rathmell@Vumc.Org
Address
777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307