Professional Bio
Tyne Miller-Fleming, PhD, is a molecular and statistical geneticist in the Division of Genetic Medicine and Clinical Pharmacology, Department of Medicine, at Vanderbilt University Medical Center (VUMC).
She received her PhD in neuroscience from Vanderbilt University, where her thesis work focused on characterizing the molecular determinants of synapse removal in GABAergic neurons in C. elegans. After completion of her doctoral degree, Dr. Miller-Fleming joined the Division of Genetic Medicine for a postdoctoral fellowship with Nancy Cox and Lea Davis through the Vanderbilt Genomic Medicine training program. During this time, she expanded her skills to include computational and statistical genetic approaches in human disease, including the analysis of genotype and whole-exome sequencing data, genome-wide association studies, polygenic risk score calculations, and imputation of gene expression. Additionally, she gained experience analyzing phenotype data extracted from medical records through phenotype algorithms, phenome-wide association studies, generation of phenotype risk scores, and laboratory-wide association scans.
Dr. Miller-Fleming's current research as a Research Instructor in Medicine aims to utilize tools developed for the study of large datasets and apply them to rare developmental diseases, including congenital anomaly syndromes, copy number variation disorders, and Mendelian diseases. She is interested in methods to evaluate the shared etiologies of rare and common disease, which were traditionally studied independently. She actively participates in working groups for Tourette syndrome within the Psychiatric Genetics Consortium (PGC) and assesses biomarkers within the PRIMED consortium.
Education
PhD - Neuroscience - Vanderbilt University, 2017
Fellowship - Division of Genetic Medicine - Vanderbilt University, 2022
Contact
Email
Kimryn.Rathmell@Vumc.Org
Address
777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307