Skip to main content
Home
Toggle menu

Give Now

  • For Patients
  • School Of Medicine
  • About
    • Leadership
    • Department Directory
    • News
    • Events
    • Annual Report
    • Nashville
  • Divisions
    • Allergy, Pulmonary and Critical Care Medicine
    • Cardiovascular Medicine
    • Diabetes, Endocrinology and Metabolism
    • Epidemiology
    • Gastroenterology, Hepatology and Nutrition
    • General Internal Medicine and Public Health
    • Genetic Medicine and Clinical Pharmacology
    • Geriatric Medicine
    • Hematology and Oncology
    • Infectious Diseases
    • Nephrology and Hypertension
    • Rheumatology and Immunology
  • Education
    • Overview
    • Internal Medicine Residency Program
    • Physician-Scientist Training Program
    • Internal Medicine-Pediatrics Residency Program
    • Fellowship Programs
    • EXCellence In TEaching Pathway
    • Physician-Scientist Doctoral Program
    • Medical Students
    • Alumni
    • Medicine Grand Rounds
  • Research
    • Overview
    • Clinical Trials
    • Publications
    • Research Centers and Labs
  • Faculty
    • Open Faculty Positions
    • Professional Development
  • Clinical Initiatives
    • Digital Health
    • Physician Builder Program

User Detail

Brett Kroncke, PhD

Assistant Professor of Medicine

Division of Genetic Medicine and Clinical Pharmacology
Brett Kroncke
Professional Bio
Brett Kroncke, PhD, is an Assistant Professor of Medicine in the Division of Genetic Medicine and Clinical Pharmacology within the Department of Medicine at Vanderbilt University Medical Center. Dr. Kroncke's research focus has been to explain the interplay between membrane protein flexibility and structure that leads to robust function and dysfunction involved in human disease, with a special emphasis on ion channels involved in the heart contraction cycle. The increasing use of next generation sequencing in the clinical arena is uncovering a large number of variants across all genes, but methods to predict their pathogenicity are not well established. This results in an increasing number of “variants of uncertain significance” (VUSs), a major emerging problem in genomic medicine. Rare variants (mutations) in the cardiac ion channels are implicated in diverse heart diseases, including long QT syndrome (LQTS), short QT syndrome (SQTS), andBrugadasyndrome (BrS), but are also common in healthy populations. While multiple algorithms predict whether ion channel variants are deleterious (SIFT,PolyPhen-2,PredSNP,CADD, etc.), too many neutral variants are classified as disease-causing. The long-term research interest of Dr. Kroncke is to improve the understanding of the clinical burden of ion channel non-synonymous single nucleotide polymorphisms (nsSNPs) on carriers. He believes predicting protein-specific functional phenotypes accurately of nsSNPs within these genes is the best path to reaching this goal, initially focused on ion channels associated with Long QT Syndrome.
Relevant Links
Vanderbilt Genetics Institute Investigators
Publications
View Publications

Education

PhD - University of Virginia, 2012

Fellowship - Biochemistry - Vanderbilt University, 2016

Fellowship - Clin Pharm - Vanderbilt University, 2018

Contact

Email 
Kimryn.Rathmell@Vumc.Org 
Address 
777 Preston Research Building 
2220 Pierce Ave 
Nashville, TN 37232-6307

Submitted by admin on Thu, 06/01/2023 - 04:28

1161 21st Ave S
Nashville, TN 37232

(615) 322-5000

Quick Links

  • Home
  • About
  • Divisions
  • Education
  • Research
  • Faculty
  • Intranet

Support Our Work

Start a fundraiser or donate to the Department of Medicine.

Give Now

Vanderbilt Health is committed to fostering an environment where everyone has the chance to thrive and is committed to the principles of equal opportunity. EOE/Vets/Disabled.

Copyright © Vanderbilt University Medical Center

sfy39587stp18