Study finds hallmarks of T cell exhaustion within hours of tumor exposure

"Surprising findings have implications for cancer immunotherapies that aim to harness the tumor-killing power of T cells, and they challenge existing ideas about how T cells become exhausted", said Mary Philip, MD, PhD, assistant professor of Medicine in the Division of Hematology and Oncology at Vanderbilt University Medical Center.

Trial seeks to expand therapies for biliary cancers

A Vanderbilt physician is leading a clinical trial that aims to unleash the full potential of immunotherapies against biliary tract cancers (BTC), which include cholangiocarcinoma and gallbladder cancer. Treatment options have been limited for BTC, which have low survival rates similar to pancreatic cancer. However, after a decade, there has been a paradigm shift in treating patients with BTC who are not eligible to have their cancer surgically removed.

Researchers clarify role of blood cell mutations in disease

More than 10% of older adults develop somatic (non-inherited) mutations in blood stem cells that can trigger explosive, clonal expansions of abnormal cells, increasing the risk for blood cancer and cardiovascular disease. Multiple DNA sequencing methods have been used to identify what is called “clonal hematopoiesis of indeterminate potential,” or CHIP, but it has been difficult to distinguish true mutations from artifacts.

New treatment helps mitigate hair loss for chemotherapy patients

Vanderbilt-Ingram Cancer Center has started offering scalp cooling, which mitigates hair loss for patients receiving certain chemotherapy regimens. 

The DigniCap Scalp Cooling System was launched this month at Vanderbilt-Ingram Cancer Center Belle Meade. It is available for patients with solid tumors from breast cancer, prostate cancer, ovarian cancer, uterine cancer and lung cancer.