Professional Bio
Jeremy Goettel, PhD, is an Assistant Professor of Medicine in the Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition at Vanderbilt University Medical Center.
He received his PhD in cell and developmental biology from Vanderbilt University in 2010, where he studied cytokine signaling in intestinal epithelial cells in the lab of Dr. Brent Polk. He performed his postdoctoral training with Dr. Scott Snapper at Harvard Medical School and Boston Children’s Hospital, where he investigated mechanisms of mucosal immune regulation with a particular focus on monogenic disorders driving inflammatory bowel diseases. During this time, Dr. Goettel developed and utilized humanized murine systems as translational research tools that enabled studies related to human immune-mediated diseases, human immunobiology, and assessing human therapeutics.
Dr. Goettel's contributions to the field of humanized mice, mucosal immunology, and inflammatory bowel disease earned him a Young Investigator Award from the International Workshop on Humanized Mice and, more recently, the prestigious CCFA Shanti Sitaraman Young IBD Investigator Award.
Dr. Goettel’s research at Vanderbilt focuses on defining the roles specific regulatory T cells and innate lymphoid cells play in mucosal immune homeostasis and inflammation-associated carcinogenesis using both genetic and humanized murine systems. His lab is interested in understanding the mechanisms regulating intestinal immunity and what leads to dysregulation and disease as well as how gut microbes shape the mucosal immune system. In particular the cytokine interleukin-23 (IL23) is required for the development of many experimental models of inflammatory bowel disease (IBD) in mice and mutations in IL23 receptor (IL23R) have been identified as susceptibility or resistance factors for Crohn’s disease.
The Goettel lab has developed several murine strains that will facilitate investigations into the role of IL23R signaling in a cell-specific manner using experimental models of IBD and inflammation-associated carcinogenesis. Additionally, the lab has developed several humanized murine systems to model intestinal inflammation driven by human immune cells and new models enabling engraftment of human tumors with autologous immune cells to assess combination therapies and immune activation. They aim for these strategies to be informative for clinical management and pave the way towards precision medicine.
Publications
Education
PhD - Cell Biology - Vanderbilt University, 2010
Contact
Email
Kimryn.Rathmell@Vumc.Org
Address
777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307