Professional Bio
Jonathan Brown, MD, is an Associate Professor of Medicine at Vanderbilt University School of Medicine, holds the Riven Family Directorship in Cardiology and is the Director of Experimental Biology in the Division of Cardiovascular Medicine at Vanderbilt University Medical Center.
He received his BA in Classics from Brown University and MD from New York Medical College. He completed internal medicine residency and a fellowship in cardiovascular medicine at Brigham and Women's Hospital/Harvard Medical School. After finishing a postdoctoral fellowship studying nuclear receptor biology, he joined the faculty at Vanderbilt University in 2015 to establish his own independent laboratory.
Dr. Brown’s research program focuses on the role of chromatin structure and chromatin-dependent signaling in cardiometabolic diseases including heart failure, atherosclerosis and metabolic disease associated with obesity. One theme focuses on how specific transcriptional coactivators drive pathologic gene expression in inflammation and fibrosis and how these programs can be disrupted with targeted small-molecule inhibitors. A second theme is examining aging and inflammation in the vasculature including in the genetic aging disease—Hutchinson-Gilford Progeria syndrome. Ongoing work seeks to develop a deeper understanding of disease regulatory circuits through integration of epigenomic and transcriptomic analysis with the goal of discovering transcriptional regulators that drive cardiometabolic diseases.
Relevant Links
Publications
Education
MD - New York Medical College, 2000
Internship - Medicine - Brigham & Women's Hospital, 2001
Residency - Medicine - Brigham & Women's Hospital, 2003
Residency - Chief-Medicine - VA Boston Healthcare, 2003
Fellowship - Cardiovascular Medicine - Brigham & Women's Hospital, 2008
Contact
Email
Kimryn.Rathmell@Vumc.Org
Address
777 Preston Research Building
2220 Pierce Ave
Nashville, TN 37232-6307