Fibroblast-derived COX-2 mitigates kidney fibrosis by modulating profibrotic macrophage activation, while its deletion promotes SPP1-associated inflammation and extracellular matrix deposition.
The SpxA1/SpxA2 regulatory balance controls stress-responsive virulence programs in Group A Streptococcus, linking cell envelope stress sensing to CovRS-mediated pathogenic gene expression.
Circulating tumor DNA enables noninvasive monitoring of treatment response, minimal residual disease, and recurrence risk, while informing precision therapy; however, optimal clinical implementation remains uncertain.
American Journal of Respiratory Cell and Molecular Biology
Multimodal analyses showed that differentiation media induces IPF-like transitional epithelial states, which are further enhanced by HIF2-biased signaling.
In a prospective US cohort of 585 patients with SARD-PPF, advanced physiologic impairment, substantial treatment burden, and high rates of progression and mortality/transplant were observed across SARD subtypes.
4,201 publications authored by Department of Medicine faculty in the last five years.
Baker, AW (Baker, Arthur W.); La Hoz, RM (La Hoz, Ricardo M.); Anesi, JA (Anesi, Judith A.); Kwon, JH (Kwon, Jennie H.); Wasylyshyn, A (Wasylyshyn, Anastasia, I); Ford, ES (Ford, Emily S.); Harrington, SM (Harrington, Susan M.); Miller, MB (Miller, Melissa B.); Weber, DJ (Weber, David J.); Sickbert-Bennett, EE (Sickbert-Bennett, Emily E.); Talbot, TR (Talbot, Thomas R.); Nguyen, MH (Nguyen, M. Hong); Kramer, KH (Kramer, Kailey Hughes); Nickel, KB (Nickel, Katelin B.); Ziegler, MJ (Ziegler, Matthew J.); Arocha, D (Arocha, Doramarie); Henderson, C (Henderson, Charles); Lokhnygina, Y (Lokhnygina, Yuliya); Maged, A (Maged, Ahmed); Haridy, S (Haridy, Salah); Alexander, BD (Alexander, Barbara D.); Stout, JE (Stout, Jason E.); Anderson, DJ (Anderson, Deverick J.)
Schulman, JA (Schulman, Jacob A.); Arora, K (Arora, Karan); Kwiatkowski, AJ (Kwiatkowski, Alexander J.); Chada, NC (Chada, Neil C.); Steele, JA (Steele, Julia A.); Pagendarm, HM (Pagendarm, Hayden M.); Woodworth, ME (Woodworth, Megan E.); Sheehy, TL (Sheehy, Taylor L.); Gibson-Corley, K (Gibson-Corley, Katherine); Balko, JM (Balko, Justin M.); Wilson, JT (Wilson, John T.)
Farber, HW (Farber, Harrison W.); Chakinala, MM (Chakinala, Murali M.); Hemnes, AR (Hemnes, Anna R.); Chin, KM (Chin, Kelly M.); Highland, KB (Highland, Kristin B.); McLaughlin, VV (McLaughlin, Vallerie V.); Melendres-Groves, LD (Melendres-Groves, Lana D.); Cho, MCL (Cho, Michelle); Doad, G (Doad, Gurinderpal); Fatehi, E (Fatehi, Elham); Han, MCL (Han, Michelle); Rahman, M (Rahman, Mohammad); Strachan, P (Strachan, Paul); Tobore, T (Tobore, Tobore); Kim, NH (Kim, Nick H.)
Connor, P (Connor, Peter); Gafford, J (Gafford, Joshua); Anderson, P (Anderson, Patrick); Webster, S (Webster, Scott); Herrell, SD III (Herrell III, S. Duke); Obstein, KL (Obstein, Keith L.); Kumar, N (Kumar, Nithesh); Rucker, C (Rucker, Caleb); Webster, RJ III (Webster III, Robert J.)