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Jonathan Casey, MD, MSCI, is a physician-scientist and clinical researcher with an appointment as an Assistant Professor for the Division of Allergy, Pulmonary, and Critical Care Medicine in the Department of Medicine at Vanderbilt University Medical Center.
Dr. Casey came to Vanderbilt from Brigham and Women's Hospital where he was a Chief Medical Resident and Instructor in Medicine at Harvard Medical School. He is a clinical researcher with a focus on designing innovative and efficient clinical trials to improve outcomes for hospitalized adults. This work is supported by grants from the NIH and Department of Defense and has spanned the gamut from proof-of-concept trials in extracorporeal membrane oxygenation (ECMO) to large comparative effectiveness trials embedded in the electronic health record.
Dr. Casey's research focuses on the comparative effectiveness of standard-of-care interventions. While traditional "explanatory" trial methods are ideal for drug discovery trials, they are too expensive and inefficient to address the innumerable treatment decisions that physicians confront every day in practice. To address this problem, Dr. Casey and the Pragmatic Critical Care Research Group (PCCRG), for which he serves as director of the Clinical Coordinating Center, has developed novel approaches to embedding "pragmatic" randomized clinical trials within clinical care to rapidly generate evidence for common management dilemmas.
His work has been published in journals such as New England Journal of Medicine, the Journal of the American Medical Association (JAMA), Lancet Respiratory Medicine, and the American Journal of Respiratory and Critical Care Medicine and has led to fundamental changes in standards of care for critically ill adults. Dr. Casey has been recognized with numerous awards for teaching and clinical research at the resident, fellow, and faculty level, and he is supported with grant funding from the NIH and department of defense.