Study: Sedative choice could improve outcomes for breathing tube patients

According to a randomized trail published last week in the New England Journal of Medicine by Allergy, Pulmonary and Critical Care Medicine Drs. Jonathan Casey and Matthew Semler, and colleagues, doctors treating seriously ill patients in an emergency room setting may want to give the sedative etomidate, rather than ketamine, when placing a breathing tube. It is the first multicenter trial to demonstrate significant cardiovascular risks of high doses of ketamine (low blood pressure, arrhythmia), side effects that have not been well studied in the past.

Large-scale integration of genomics, proteomics and clinical records identifies cancer risk proteins and potential therapeutics

Researchers at VUMC and the University of Calgary have established an analytical framework that integrates genomic, proteomic and electronic health record data to identify cancer risk proteins and therapeutics for cancer prevention. The study, reported Dec. 2 in the American Journal of Human Genetics by co-senior author Xingyi Guo, PhD (Epidemiology), and colleagues, identifies previously unreported protein biomarkers and candidate drug targets across six major cancer types and highlights approved drugs with potential cancer preventive effects.