Study finds hallmarks of T cell exhaustion within hours of tumor exposure

"Surprising findings have implications for cancer immunotherapies that aim to harness the tumor-killing power of T cells, and they challenge existing ideas about how T cells become exhausted", said Mary Philip, MD, PhD, assistant professor of Medicine in the Division of Hematology and Oncology at Vanderbilt University Medical Center.

Trial seeks to expand therapies for biliary cancers

A Vanderbilt physician is leading a clinical trial that aims to unleash the full potential of immunotherapies against biliary tract cancers (BTC), which include cholangiocarcinoma and gallbladder cancer. Treatment options have been limited for BTC, which have low survival rates similar to pancreatic cancer. However, after a decade, there has been a paradigm shift in treating patients with BTC who are not eligible to have their cancer surgically removed.